Table 2 Demographic, clinical and biochemical parameters in 198 APAP-ALF patients by outcome (admission)
Early (admission) | APAP alive day 21 (n = 99) | APAP dead day 21 (n = 99) | p value | ||
|---|---|---|---|---|---|
N | Number (%) or median (IQR) | N | Number (%) or median (IQR) | ||
Biochemistry | |||||
Hemoglobin (g/dl) | 99 | 10.4 (9.2–12.5) | 97 | 10.9 (9.5–12.2) | 0.52 |
White blood count (109/l) | 98 | 8.6 (6.4–11.2) | 97 | 10.9 (7.3–17.5) | 0.0008 |
Platelet count (109/l) | 98 | 132.5 (90.0–195.0) | 97 | 110.0 (67.0–160.0) | 0.0045 |
INR | 99 | 2.7 (1.8–4.1) | 96 | 3.4 (2.3–4.8) | 0.0023 |
ALT (IU/l) | 98 | 3380 (1949–6576) | 99 | 3235 (1483–5716) | 0.37 |
Bilirubin (mg/dl) | 98 | 4.1 (2.5–5.6) | 99 | 5.0 (3.6–7.8) | < 0.0001 |
pH | 88 | 7.4 (7.4–7.5) | 88 | 7.4 (7.3–7.5) | 0.22 |
Ammonia (venous) (μmol/l) | 51 | 92 (73–140) | 32 | 139 (72–205) | 0.068 |
Creatinine (mg/dl) | 98 | 1.4 (0.8–3.0) | 98 | 2.6 (1.2–3.8) | 0.0007 |
Lactate (mmol/l) | 71 | 2.8 (1.7–5.5) | 68 | 7.0 (4.8–11.8) | < 0.0001 |
Phosphate (mg/dl) | 88 | 2.3 (1.7–3.4) | 76 | 3.2 (2.1–4.5) | 0.0061 |
MELD | 98 | 23.4 (12.7–27.7) | 96 | 29.1 (23.8–34.5) | < 0.0001 |
High coma grade (3 or 4) | 99 | 56 (57%) | 97 | 69 (71%) | 0.034 |
Organ support | |||||
Mechanical ventilation | 99 | 57(58%) | 99 | 79 (80%) | 0.0007 |
Vasopressors | 99 | 9 (9%) | 99 | 42 (42%) | < 0.0001 |
Renal replacement therapy | 99 | 19 (19%) | 99 | 24 (24%) | 0.39 |
FABP7 (ng/ml) | 99 | 147.9 (66.6–296.2) | 99 | 316.5 (119.8–562.2) | 0.0002 |
Late (n = 186) | APAP alive day 21 (n = 99) | APAP dead day 21 (n = 87) | p value | ||
|---|---|---|---|---|---|
Late (days 3–5) | N | Number (%) or median (IQR) | N | Number (%) or median (IQR) | |
Biochemistry | |||||
Hemoglobin (g/dl) | 94 | 9.9 (9.0–11.1) | 81 | 10.2 (9.2–10.9) | 0.63 |
White blood count (109/L) | 94 | 8.1 (5.9–11.6) | 81 | 11.3 (7.1–15.0) | 0.0029 |
Platelet count (109/L) | 95 | 111.0 (68.0–153.0) | 81 | 66.0 (47.0–100.0) | < 0.0001 |
INR | 94 | 1.5 (1.3–1.8) | 75 | 2.5 (1.8–4.4) | < 0.0001 |
ALT (IU/L) | 94 | 1172 (612–2007) | 78 | 938 (383–1995) | 0.31 |
Bilirubin (mg/dl) | 92 | 5.5 (2.7–8.2) | 78 | 9.8 (6.7–13.7) | < 0.0001 |
pH | 55 | 7.4 (7.4–7.5) | 76 | 7.4 (7.3–7.5) | 0.042 |
Ammonia (venous) (μmol/L) | 25 | 62 (44–84) | 17 | 119 (78–133) | 0.0038 |
Creatinine (mg/dl) | 94 | 1.2 (0.7–2.5) | 82 | 2.4 (1.3–4.0) | < 0.0001 |
Lactate (mmol/L) | 31 | 1.7 (1.0–2.2) | 41 | 3.8 (2.6–6.7) | < 0.0001 |
Phosphate (mg/dl) | 73 | 2.8 (2.3–3.6) | 35 | 3.3 (2.5–4.5) | 0.054 |
PO2/FiO2 ratio | 48 | 3.3 (2.1–4.5) | 71 | 2.5 (1.4–3.9) | 0.0087 |
MELD | 87 | 14.2 (5.4–24.6) | 73 | 29.7 (23.5–35.4) | < 0.0001 |
High coma grade (3 or 4)a | 59 | 35 (59%) | 82 | 72 (88%) | < 0.0001 |
Organ support | |||||
Mechanical ventilation | 99 | 49 (49%) | 88 | 74 (85%) | < 0.0001 |
Vasopressors | 99 | 5 (5%) | 88 | 45 (52%) | < 0.0001 |
Renal replacement therapy | 99 | 10 (19%) | 88 | 27 (31%) | 0.062 |
FABP7 (ng/ml) | 99 | 87.3 (48.0–261.5) | 87 | 286.2 (146.7–536.9) | < 0.0001 |