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Table 2 Demographic, clinical and biochemical parameters in 198 APAP-ALF patients by outcome (admission)

From: The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study

Early (admission) APAP alive day 21 (n = 99) APAP dead day 21 (n = 99) p value
N Number (%) or median (IQR) N Number (%) or median (IQR)
Biochemistry      
 Hemoglobin (g/dl) 99 10.4 (9.2–12.5) 97 10.9 (9.5–12.2) 0.52
 White blood count (109/l) 98 8.6 (6.4–11.2) 97 10.9 (7.3–17.5) 0.0008
 Platelet count (109/l) 98 132.5 (90.0–195.0) 97 110.0 (67.0–160.0) 0.0045
 INR 99 2.7 (1.8–4.1) 96 3.4 (2.3–4.8) 0.0023
 ALT (IU/l) 98 3380 (1949–6576) 99 3235 (1483–5716) 0.37
 Bilirubin (mg/dl) 98 4.1 (2.5–5.6) 99 5.0 (3.6–7.8) < 0.0001
 pH 88 7.4 (7.4–7.5) 88 7.4 (7.3–7.5) 0.22
 Ammonia (venous) (μmol/l) 51 92 (73–140) 32 139 (72–205) 0.068
 Creatinine (mg/dl) 98 1.4 (0.8–3.0) 98 2.6 (1.2–3.8) 0.0007
 Lactate (mmol/l) 71 2.8 (1.7–5.5) 68 7.0 (4.8–11.8) < 0.0001
 Phosphate (mg/dl) 88 2.3 (1.7–3.4) 76 3.2 (2.1–4.5) 0.0061
MELD 98 23.4 (12.7–27.7) 96 29.1 (23.8–34.5) < 0.0001
High coma grade (3 or 4) 99 56 (57%) 97 69 (71%) 0.034
Organ support      
 Mechanical ventilation 99 57(58%) 99 79 (80%) 0.0007
 Vasopressors 99 9 (9%) 99 42 (42%) < 0.0001
 Renal replacement therapy 99 19 (19%) 99 24 (24%) 0.39
FABP7 (ng/ml) 99 147.9 (66.6–296.2) 99 316.5 (119.8–562.2) 0.0002
Late (n = 186) APAP alive day 21 (n = 99) APAP dead day 21 (n = 87) p value
Late (days 3–5) N Number (%) or median (IQR) N Number (%) or median (IQR)
Biochemistry      
 Hemoglobin (g/dl) 94 9.9 (9.0–11.1) 81 10.2 (9.2–10.9) 0.63
 White blood count (109/L) 94 8.1 (5.9–11.6) 81 11.3 (7.1–15.0) 0.0029
 Platelet count (109/L) 95 111.0 (68.0–153.0) 81 66.0 (47.0–100.0) < 0.0001
 INR 94 1.5 (1.3–1.8) 75 2.5 (1.8–4.4) < 0.0001
 ALT (IU/L) 94 1172 (612–2007) 78 938 (383–1995) 0.31
 Bilirubin (mg/dl) 92 5.5 (2.7–8.2) 78 9.8 (6.7–13.7) < 0.0001
 pH 55 7.4 (7.4–7.5) 76 7.4 (7.3–7.5) 0.042
 Ammonia (venous) (μmol/L) 25 62 (44–84) 17 119 (78–133) 0.0038
 Creatinine (mg/dl) 94 1.2 (0.7–2.5) 82 2.4 (1.3–4.0) < 0.0001
 Lactate (mmol/L) 31 1.7 (1.0–2.2) 41 3.8 (2.6–6.7) < 0.0001
 Phosphate (mg/dl) 73 2.8 (2.3–3.6) 35 3.3 (2.5–4.5) 0.054
PO2/FiO2 ratio 48 3.3 (2.1–4.5) 71 2.5 (1.4–3.9) 0.0087
MELD 87 14.2 (5.4–24.6) 73 29.7 (23.5–35.4) < 0.0001
High coma grade (3 or 4)a 59 35 (59%) 82 72 (88%) < 0.0001
Organ support      
 Mechanical ventilation 99 49 (49%) 88 74 (85%) < 0.0001
 Vasopressors 99 5 (5%) 88 45 (52%) < 0.0001
 Renal replacement therapy 99 10 (19%) 88 27 (31%) 0.062
FABP7 (ng/ml) 99 87.3 (48.0–261.5) 87 286.2 (146.7–536.9) < 0.0001
  1. N frequency, IQR interquartile range, INR international normalized ratio, AST aspartate aminotransferase, ALT alanine aminotransferase, MELD model for end-stage liver disease
  2. aHepatic encephalopathy grade according to West Haven criteria