|
Early
|
Unadjusted
|
Multivariable model (N = 194), AUROC = 0.766
|
|---|
|
N
|
OR
|
95% OR CI
|
p value
|
Included in Model
|
OR
|
95% CI
|
p value
|
|---|
|
FABP7
|
198
|
1.001
|
(1.000, 1.002)
|
0.0078
|
Yes
|
1.001
|
(1.000, 1.001)
|
0.18
|
|
MELD
|
194
|
1.083
|
(1.047, 1.119)
|
< 0.0001
|
Yes
|
1.056
|
(1.020, 1.093)
|
0.0021
|
|
Lactate
|
132
|
1.205
|
(1.095, 1.327)
|
0.0001
|
No
| | | |
|
Vasopressors
|
198
|
7.368
|
(3.335, 16.287)
|
< 0.0001
|
Yes
|
4.138
|
(1.769, 9.677)
|
0.0011
|
|
Renal replacement therapy
|
198
|
1.347
|
(0.683, 2.658)
|
0.390
|
No
| | | |
|
Mechanical ventilation
|
198
|
2.910
|
(1.547, 5.475)
|
0.0009
|
No
| | | |
|
High coma grade (3 or 4)
|
196
|
1.892
|
(1.047, 3.421)
|
0.0348
|
No
| | | |
|
Late (days 3–5)
|
Unadjusted
|
Multivariable model (N = 160), AUROC = 0.891
|
|---|
|
N
|
OR
|
95% OR CI
|
p value
|
Included in model
|
OR
|
95% CI
|
p value
|
|---|
|
FABP7
|
186
|
1.003
|
(1.001, 1.004)
|
0.0001
|
Yes
|
1.001
|
(0.999, 1.003)
|
0.40
|
|
MELD
|
160
|
1.115
|
(1.075, 1.157)
|
< 0.0001
|
Yes
|
1.084
|
(1.038, 1.132)
|
0.0003
|
|
Lactate
|
71
|
6.908
|
(2.592, 18.406)
|
0.0001
|
No
| | | |
|
Vasopressors
|
186
|
20.143
|
(7.462, 54.370)
|
< 0.0001
|
Yes
|
20.419
|
(6.221, 67.021)
|
<0.0001
|
|
Renal replacement therapy
|
186
|
1.895
|
(0.964, 3.724)
|
0.0638
|
No
| | | |
|
Mechanical ventilation
|
186
|
5.808
|
(2.859, 11.802)
|
< 0.0001
|
No
| | | |
|
High coma grade (3 or 4)
|
141
|
4.936
|
(2.129, 11.446)
|
0.0002
|
No
| | | |
- Early: lactate (p = 0.52), high coma grade (p = 0.46), and mechanical ventilator (p = 0.084) were not significant on multivariable analysis so not included in the final early model
- Late: mechanical ventilation (p = 0.69) and high coma grade (p = 0.53) were not significant on multivariable analysis so not included in the final late model. Lactate was not included due to missing data
