Annals of Intensive Care

Table 3 Early (day 1) and late (days 3–5) predictors of 21-day mortality in 198 APAP-ALF patients

From: The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study

Early	Unadjusted				Multivariable model (N = 194), AUROC = 0.766
Early	N	OR	95% OR CI	p value	Included in Model	OR	95% CI	p value
FABP7	198	1.001	(1.000, 1.002)	0.0078	Yes	1.001	(1.000, 1.001)	0.18
MELD	194	1.083	(1.047, 1.119)	< 0.0001	Yes	1.056	(1.020, 1.093)	0.0021
Lactate	132	1.205	(1.095, 1.327)	0.0001	No
Vasopressors	198	7.368	(3.335, 16.287)	< 0.0001	Yes	4.138	(1.769, 9.677)	0.0011
Renal replacement therapy	198	1.347	(0.683, 2.658)	0.390	No
Mechanical ventilation	198	2.910	(1.547, 5.475)	0.0009	No
High coma grade (3 or 4)	196	1.892	(1.047, 3.421)	0.0348	No

Late (days 3–5)	Unadjusted				Multivariable model (N = 160), AUROC = 0.891
Late (days 3–5)	N	OR	95% OR CI	p value	Included in model	OR	95% CI	p value
FABP7	186	1.003	(1.001, 1.004)	0.0001	Yes	1.001	(0.999, 1.003)	0.40
MELD	160	1.115	(1.075, 1.157)	< 0.0001	Yes	1.084	(1.038, 1.132)	0.0003
Lactate	71	6.908	(2.592, 18.406)	0.0001	No
Vasopressors	186	20.143	(7.462, 54.370)	< 0.0001	Yes	20.419	(6.221, 67.021)	<0.0001
Renal replacement therapy	186	1.895	(0.964, 3.724)	0.0638	No
Mechanical ventilation	186	5.808	(2.859, 11.802)	< 0.0001	No
High coma grade (3 or 4)	141	4.936	(2.129, 11.446)	0.0002	No

Early: lactate (p = 0.52), high coma grade (p = 0.46), and mechanical ventilator (p = 0.084) were not significant on multivariable analysis so not included in the final early model
Late: mechanical ventilation (p = 0.69) and high coma grade (p = 0.53) were not significant on multivariable analysis so not included in the final late model. Lactate was not included due to missing data

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