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Table 3 Early (day 1) and late (days 3–5) predictors of 21-day mortality in 198 APAP-ALF patients

From: The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study

Early Unadjusted Multivariable model (N = 194), AUROC = 0.766
N OR 95% OR CI p value Included in Model OR 95% CI p value
FABP7 198 1.001 (1.000, 1.002) 0.0078 Yes 1.001 (1.000, 1.001) 0.18
MELD 194 1.083 (1.047, 1.119) < 0.0001 Yes 1.056 (1.020, 1.093) 0.0021
Lactate 132 1.205 (1.095, 1.327) 0.0001 No    
Vasopressors 198 7.368 (3.335, 16.287) < 0.0001 Yes 4.138 (1.769, 9.677) 0.0011
Renal replacement therapy 198 1.347 (0.683, 2.658) 0.390 No    
Mechanical ventilation 198 2.910 (1.547, 5.475) 0.0009 No    
High coma grade (3 or 4) 196 1.892 (1.047, 3.421) 0.0348 No    
Late (days 3–5) Unadjusted Multivariable model (N = 160), AUROC = 0.891
N OR 95% OR CI p value Included in model OR 95% CI p value
FABP7 186 1.003 (1.001, 1.004) 0.0001 Yes 1.001 (0.999, 1.003) 0.40
MELD 160 1.115 (1.075, 1.157) < 0.0001 Yes 1.084 (1.038, 1.132) 0.0003
Lactate 71 6.908 (2.592, 18.406) 0.0001 No    
Vasopressors 186 20.143 (7.462, 54.370) < 0.0001 Yes 20.419 (6.221, 67.021) <0.0001
Renal replacement therapy 186 1.895 (0.964, 3.724) 0.0638 No    
Mechanical ventilation 186 5.808 (2.859, 11.802) < 0.0001 No    
High coma grade (3 or 4) 141 4.936 (2.129, 11.446) 0.0002 No    
  1. Early: lactate (p = 0.52), high coma grade (p = 0.46), and mechanical ventilator (p = 0.084) were not significant on multivariable analysis so not included in the final early model
  2. Late: mechanical ventilation (p = 0.69) and high coma grade (p = 0.53) were not significant on multivariable analysis so not included in the final late model. Lactate was not included due to missing data