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Table 4 Early (admission) and late (days 3–5) predictors of cerebral edema in 150 APAP-ALF patients

From: The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study

Early

Unadjusted

Multivariable model (N = 148), AUROC = 0.590

N

OR

95% OR CI

p value

Included in model

OR

95% CI

p value

FABP7

150

1.000

(1.000, 1.001)

0.58

Yes

1.000

(1.000, 1.001)

0.65

MELD

146

1.036

(0.997, 1.078)

0.072

No

   

Lactate

100

1.000

(0.997, 1.002)

0.80

No

   

Vasopressors

150

0.777

(0.363, 1.660)

0.51

No

   

Renal replacement therapy

150

1.313

(0.598, 2.886)

0.50

No

   

Mechanical ventilation

150

2.950

(1.199, 7.257)

0.019

Yes

2.880

(1.166, 7.111)

0.022

High coma grade (3 or 4)

148

2.227

(1.017, 4.878)

0.045

No

   

Late (days 3–5)

Unadjusted

Multivariable model (N = 113), AUROC = 0.641

N

OR

95% OR CI

p value

Included in model

OR

95% CI

p value

FABP7

138

1.000

(0.999, 1.001)

0.96

Yes

1.000

(0.999, 1.001)

0.57

MELD

118

1.030

(0.994, 1.066)

0.10

No

   

Lactate

53

1.031

(0.979, 1.086)

0.25

No

   

Vasopressors

138

2.043

(0.947, 4.408)

0.069

No

   

Renal replacement therapy

138

1.756

(0.789, 3.909)

0.17

No

   

Mechanical ventilation

138

10.115

(2.300, 44.491)

0.0022

No

   

High coma grade (3 or 4)*

113

24.324

(1.326, 446.243)

0.0316

Yes

25.759

(1.404, 472.46)

0.029

  1. Early: high coma grade (p = 0.69) was not significant on multivariable analysis so not included in the final early model
  2. Late: mechanical ventilation (p = 0.65) was not significant on multivariable analysis so not included in the final late model
  3. *Statistically significant on multivariable analysis