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Table 4 Early (admission) and late (days 3–5) predictors of cerebral edema in 150 APAP-ALF patients

From: The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study

Early Unadjusted Multivariable model (N = 148), AUROC = 0.590
N OR 95% OR CI p value Included in model OR 95% CI p value
FABP7 150 1.000 (1.000, 1.001) 0.58 Yes 1.000 (1.000, 1.001) 0.65
MELD 146 1.036 (0.997, 1.078) 0.072 No    
Lactate 100 1.000 (0.997, 1.002) 0.80 No    
Vasopressors 150 0.777 (0.363, 1.660) 0.51 No    
Renal replacement therapy 150 1.313 (0.598, 2.886) 0.50 No    
Mechanical ventilation 150 2.950 (1.199, 7.257) 0.019 Yes 2.880 (1.166, 7.111) 0.022
High coma grade (3 or 4) 148 2.227 (1.017, 4.878) 0.045 No    
Late (days 3–5) Unadjusted Multivariable model (N = 113), AUROC = 0.641
N OR 95% OR CI p value Included in model OR 95% CI p value
FABP7 138 1.000 (0.999, 1.001) 0.96 Yes 1.000 (0.999, 1.001) 0.57
MELD 118 1.030 (0.994, 1.066) 0.10 No    
Lactate 53 1.031 (0.979, 1.086) 0.25 No    
Vasopressors 138 2.043 (0.947, 4.408) 0.069 No    
Renal replacement therapy 138 1.756 (0.789, 3.909) 0.17 No    
Mechanical ventilation 138 10.115 (2.300, 44.491) 0.0022 No    
High coma grade (3 or 4)* 113 24.324 (1.326, 446.243) 0.0316 Yes 25.759 (1.404, 472.46) 0.029
  1. Early: high coma grade (p = 0.69) was not significant on multivariable analysis so not included in the final early model
  2. Late: mechanical ventilation (p = 0.65) was not significant on multivariable analysis so not included in the final late model
  3. *Statistically significant on multivariable analysis