Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction

Annals of Intensive Care

Table 1 Clinical characteristics of 262 critically ill medical ICU patients with severe sepsis who were included in the study

	All patients N = 262	Non-pulmonary sepsis N = 127	Pulmonary sepsis N = 135	p value
Age (years)	56 ± 16	56 ± 15	56 ± 17	0.98
Male	137 (52%)	63 (50%)	74 (55%)	0.46
Caucasian	224 (86%)	107 (84%)	117 (87%)	0.60
Ever smoker	149 (57%)	68 (54%)	82 (61%)	0.26
Alcohol abuse	55 (21%)	26 (21%)	30 (22%)	0.77
APACHE II	34 ± 6	34 ± 6	33 ± 6	0.06
Primary site of infection
Lung			134 (100%)
Abdomen		32 (25%)
Urinary tract		23 (18%)
Skin/soft tissue/bone		17 (13%)
CNS/sinus		17 (13%)
Endocarditis/catheter		25 (20%)
Other or unclear		13 (10%)
Required vasopressors		81 (64%)	69 (51%)	0.05
Developed ARDS	135 (52%)	56 (44%)	79 (59%)	0.03
Ventilator-free days 150 (57%)	14 ± 11	14 ± 11	14 ± 11	0.98
Died in hospital	94 (36%)	48 (38%)	46 (34%)	0.61

Data as mean ± SD or n (%) as indicated. p values compare characteristics of groups with pulmonary versus non-pulmonary sepsis by T test or Chi-square analysis as appropriate