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Table 1 The baseline characteristics of the enrolled patients (n = 510)

From: Effects of combination therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation

Factors

Monotherapy group

n = 282

Combination therapy group

n = 228

P value

Missing value

Survival at day 28 (%)

 No

81 (28.7)

51 (22.4)

0.127

0

 Yes

201 (71.3)

177 (77.6)

  

Age (mean [SD])

71.7 (14.7)

72.3 (15.6)

0.663

0

Sex (%)

 Female

115 (40.8)

88 (38.6)

0.682

0

 Male

167 (59.2)

140 (61.4)

  

Infection focus (n, %)

 Respiratory system

91 (32.3)

60 (26.3)

0.172

0

 Gastrointestinal system

69 (24.5)

66 (28.9)

0.268

0

 Biliary system

35 (12.4)

28 (12.3)

1.000

0

 Urinary system

36 (12.8)

39 (17.1)

0.208

0

 Musculoskeletal

17 (6.0)

7 (3.1)

0.142

0

 Skin and soft tissue

10 (3.5)

7 (3.1)

0.809

0

 Central nerve system

2 (0.7)

2 (0.9)

1.000

0

 Other

13 (4.6)

15 (6.6)

0.337

0

 Unknown

35 (12.4)

20 (8.8)

0.199

0

Surgical intervention

23 (8.2)

34 (14.9)

0.023

0

Non-surgical drainage#

5 (1.8)

10 (4.4)

0.113

0

Baseline SOFA score median [25, 75%]

 Total SOFA

10.0 [7.0, 13.0]

11.0 [8.0, 13.0]

0.062

120

 Coagulation

2.0 [1.0, 3.0]

2.0 [1.0, 3.0]

0.402

15

 Hepatic

0.0 [0.0, 2.0]

0.0 [0.0, 1.0]

0.020

33

 Cardiovascular

2.0 [0.0, 4.0]

3.0 [0.3, 4.0]

0.001

19

 CNS system

2.0 [0.0, 3.0]

2.0 [1.0, 3.0]

0.312

60

 Renal system

1.0 [0.0, 2.0]

1.0 [0.0, 2.0]

0.140

21

 Respiratory system

2.0 [1.0, 3.0]

2.0 [1.0, 3.0]

0.038

88

Baseline DIC score median [25, 75%]

 Total DIC score

5.0 [4.0, 6.0]

5.0 [4.0, 7.0]

0.039

29

 SIRS score (n, %)

  0 point

130 (46.4)

77 (34.4)

  

  1 point

150 (53.6)

147 (65.6)

0.006

6

 Platelet score

3.0 [1.0, 3.0]

3.0 [1.0, 3.0]

0.182

1

 FDP score

3.0 [1.0, 3.0]

3.0 [1.0, 3.0]

0.242

14

 PT ratio score (n, %)

  0 point

53 (19.9)

33 (14.5)

  

  1 point

214 (80.1)

195 (85.5)

0.123

15

Baseline laboratory score median (SD)

 Platelet count (× 109/L)

99.5 (77.6)

89.6 (68.1)

0.130

1

 FDP (μg/mL)

56.6 (150.3)

48.8 (66.7)

0.526

110

 D-dimer (μg/mL)

26.8 (46.7)

19.7 (29.1)

0.053

121

 PT ratio

1.97 (6.08)

1.55 (0.52)

0.298

15

 Antithrombin activity (%)

49.6 (13.8)

47.3 (12.7)

0.058

17

  1. The data were shown as mean (standard deviation; SD) or median [25th percentile, 75th percentile]
  2. As the SIRS score and the PT ratio score were composed of binary data, Fisher’s exact test was performed
  3. Non-surgical interventions are as follows: percutaneous transcatheter abscess drainage, urinary tract stenting, biliary tract stenting
  4. n number, SOFA sequential organ failure assessment, CNS central nervous system, DIC disseminated intravascular coagulation, SIRS systemic inflammatory response syndrome, FDP fibrinogen/fibrin degradation products, PT prothrombin time
  5. # For the selection of covariates, a variance inflation factor (VIF) was calculated and the covariates with VIF 5 were excluded. Finally, age, sex, baseline SOFA score, baseline DIC score, and antithrombin activityused were selected.