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Table 2 The baseline characteristics of the patients after propensity score matching (n = 258)

From: Effects of combination therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation

Factors

Monotherapy group

n = 129

Combination therapy group

n = 129

P value

Effect size

Age, mean (SD)

73.3 (12.0)

73.8 (11.5)

0.723

0.044a

Sex (n, %)

    

 Female

54 (41.9)

52 (40.3)

0.899

0.064a

 Male

75 (58.1)

77 (59.7)

  

Infection focus (n, %)

 Respiratory system

58 (45.0)

38 (29.5)

0.014

0.160

 Gastrointestinal system

22 (17.1)

34 (26.4)

0.096

0.113

 Biliary system

19 (14.7)

15 (11.6)

0.581

0.046

 Urinary system

12 (9.3)

23 (17.8)

0.068

0.125

 Musculoskeletal

8 (6.2)

4 (3.1)

0.376

0.074

 Skin and soft tissue

5 (3.9)

3 (2.3)

0.722

0.045

 Central nerve system

0

1 (0.8)

1.000

0.062

 Others

3 (2.3)

8 (6.2)

0.216

0.096

 Unknown

14 (10.9)

12 (9.3)

0.837

0.026

Surgical intervention

8 (6.2)

19 (14.7)

0.040

0.139

Non-surgical drainage#

1 (0.8)

4 (3.1)

0.370

0.084

Baseline SOFA score median [25, 75%]

 Total SOFA

10.7 [2.0, 22.0]

10.8 [3.0, 19.0]

0.849a

0.025a

 Hepatic

1.0 [0.0, 3.0]

0.0 [0.0, 3.0]

0.015

0.182

 Cardiovascular

3.0 [0.0, 4.0]

3.0 [0.0, 4.0]

0.266

0.151

 CNS system

2.0 [0.0, 4.0]

2.0 [0.0, 4.0]

0.678

0.026

Renal system

1.0 [0.0, 4.0]

1.0 [0.0, 4.0]

0.656

0.028

 Respiratory system

2.0 [0.0, 4.0]

2.0 [0.0, 4.0]

0.266

0.069

Baseline DIC score Median [25, 75%]

 Total DIC score

5.7 [2.0, 8.0]

5.7 [2.0, 8.0]

0.935a

0.013a

 SIRS score (n, %)

  0 point

51 (39.5)

37 (28.7)

  

  1 point

78 (60.5)

92 (71.3)

0.088

0.114

 Platelet score

3.0 [0.0, 3.0]

3.0 [0.0, 3.0]

0.778

0.048

 FDP score

3.0 [0.0, 3.0]

3.0 [0.0, 3.0]

0.829

0.105

 PT ratio score (n, %)

  0 point

15 (11.6)

21 (16.3)

  

  1 point

114 (88.4)

108 (83.7)

0.369

0.067

Baseline laboratory score mean (SD)

 Platelet count (× 109/L)

8.60 (6.29)

8.47 (5.04)

0.853

0.023

 FDP (μg/mL)

73.9 (191.1)

51.11 (73.35)

0.206

0.158

 D-dimer (μg/mL)

28.3 (48.9)

21.1 (24.3)

0.166

0.185

 PT ratio

2.42 (8.68)

1.50 (0.41)

0.232

0.150

 Antithrombin activity (%)

45.6 (14.1)

47.7 (11.7)

0.928

0.011a

  1. # For the selection of covariates, a variance inflation factor (VIF) was calculated and the covariates with VIF 5 were excluded. Finally, age, sex, baseline SOFA score, baseline DIC score, and antithrombin activityused were selected.
  2. aConfounding covariates used by the propensity score (age, sex, baseline SOFA score, baseline DIC score, and antithrombin activity)
  3. Non-surgical interventions are as follows: percutaneous transcatheter abscess drainage, urinary tract stenting, biliary tract stenting
  4. When the basic assumptions of Student’s t test were satisfied, data were shown mean (standard deviation) and the effect size was calculated using Cohen’s d. When the basic assumptions of Student’s t test were not satisfied, Mann–Whitney U test was performed and data were shown median [25 percentiles, 75 percentiles]. And the effect size was calculated using the following formula, Z-scores/a square root of sample number. For two-by-two contingency table, phi coefficient was used
  5. n number, SD standard deviation, SOFA sequential organ failure assessment, DIC disseminated intravascular coagulation