Factors | Monotherapy group n = 129 | Combination therapy group n = 129 | P value | Effect size |
---|---|---|---|---|
Age, mean (SD) | 73.3 (12.0) | 73.8 (11.5) | 0.723 | 0.044a |
Sex (n, %) | ||||
Female | 54 (41.9) | 52 (40.3) | 0.899 | 0.064a |
Male | 75 (58.1) | 77 (59.7) | ||
Infection focus (n, %) | ||||
Respiratory system | 58 (45.0) | 38 (29.5) | 0.014 | 0.160 |
Gastrointestinal system | 22 (17.1) | 34 (26.4) | 0.096 | 0.113 |
Biliary system | 19 (14.7) | 15 (11.6) | 0.581 | 0.046 |
Urinary system | 12 (9.3) | 23 (17.8) | 0.068 | 0.125 |
Musculoskeletal | 8 (6.2) | 4 (3.1) | 0.376 | 0.074 |
Skin and soft tissue | 5 (3.9) | 3 (2.3) | 0.722 | 0.045 |
Central nerve system | 0 | 1 (0.8) | 1.000 | 0.062 |
Others | 3 (2.3) | 8 (6.2) | 0.216 | 0.096 |
Unknown | 14 (10.9) | 12 (9.3) | 0.837 | 0.026 |
Surgical intervention | 8 (6.2) | 19 (14.7) | 0.040 | 0.139 |
Non-surgical drainage# | 1 (0.8) | 4 (3.1) | 0.370 | 0.084 |
Baseline SOFA score median [25, 75%] | ||||
Total SOFA | 10.7 [2.0, 22.0] | 10.8 [3.0, 19.0] | 0.849a | 0.025a |
Hepatic | 1.0 [0.0, 3.0] | 0.0 [0.0, 3.0] | 0.015 | 0.182 |
Cardiovascular | 3.0 [0.0, 4.0] | 3.0 [0.0, 4.0] | 0.266 | 0.151 |
CNS system | 2.0 [0.0, 4.0] | 2.0 [0.0, 4.0] | 0.678 | 0.026 |
Renal system | 1.0 [0.0, 4.0] | 1.0 [0.0, 4.0] | 0.656 | 0.028 |
Respiratory system | 2.0 [0.0, 4.0] | 2.0 [0.0, 4.0] | 0.266 | 0.069 |
Baseline DIC score Median [25, 75%] | ||||
Total DIC score | 5.7 [2.0, 8.0] | 5.7 [2.0, 8.0] | 0.935a | 0.013a |
SIRS score (n, %) | ||||
0 point | 51 (39.5) | 37 (28.7) | ||
1 point | 78 (60.5) | 92 (71.3) | 0.088 | 0.114 |
Platelet score | 3.0 [0.0, 3.0] | 3.0 [0.0, 3.0] | 0.778 | 0.048 |
FDP score | 3.0 [0.0, 3.0] | 3.0 [0.0, 3.0] | 0.829 | 0.105 |
PT ratio score (n, %) | ||||
0 point | 15 (11.6) | 21 (16.3) | ||
1 point | 114 (88.4) | 108 (83.7) | 0.369 | 0.067 |
Baseline laboratory score mean (SD) | ||||
Platelet count (× 109/L) | 8.60 (6.29) | 8.47 (5.04) | 0.853 | 0.023 |
FDP (μg/mL) | 73.9 (191.1) | 51.11 (73.35) | 0.206 | 0.158 |
D-dimer (μg/mL) | 28.3 (48.9) | 21.1 (24.3) | 0.166 | 0.185 |
PT ratio | 2.42 (8.68) | 1.50 (0.41) | 0.232 | 0.150 |
Antithrombin activity (%) | 45.6 (14.1) | 47.7 (11.7) | 0.928 | 0.011a |