Table 4 (Adapted from Bonomo and Van Duin) Activity in clinical practice of different beta-lactamase inhibitors, according to type of enzymes [68, 111]
From: Piperacillin–tazobactam as alternative to carbapenems for ICU patients
Enzymes | Class | Substrates | Clavulanic acid | Sulbactam | Tazobactam | Avibactam |
|---|---|---|---|---|---|---|
TEM-1, TEM-2, SHV-1 | A | Penicillins, early cephalosporins | + | – | + | + |
TEM-3, SHV-2 CTX-M-14 | A | Extended-spectrum cephalosporins, monobactams | – | – | + | + |
KPC-2, KPC-3 | A | Broad spectrum including carbapenems | – | – | – | + |
IMP-1, NDM-1, VIM-1 | B | Broad spectrum including carbapenems, but not monobactams | – | – | – | – |
Escherichia coli AmpC | C | Cephalosporins | – | – | ± | + |
OXA-48 | D | Carbapenem | – | – | – | + |