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Table 4 (Adapted from Bonomo and Van Duin) Activity in clinical practice of different beta-lactamase inhibitors, according to type of enzymes [68, 111]

From: Piperacillin–tazobactam as alternative to carbapenems for ICU patients

Enzymes Class Substrates Clavulanic acid Sulbactam Tazobactam Avibactam
TEM-1, TEM-2, SHV-1 A Penicillins, early cephalosporins + + +
TEM-3, SHV-2 CTX-M-14 A Extended-spectrum cephalosporins, monobactams + +
KPC-2, KPC-3 A Broad spectrum including carbapenems +
IMP-1, NDM-1, VIM-1 B Broad spectrum including carbapenems, but not monobactams
Escherichia coli AmpC C Cephalosporins ± +
OXA-48 D Carbapenem +