TY - JOUR AU - Gong, L. AU - Goswami, S. AU - Giacomini, K. M. AU - Altman, R. B. AU - Klein, T. E. PY - 2012 DA - 2012// TI - Metformin pathways: pharmacokinetics and pharmacodynamics JO - Pharmacogenet Genomics VL - 22 UR - https://doi.org/10.1097/FPC.0b013e3283559b22 DO - 10.1097/FPC.0b013e3283559b22 ID - Gong2012 ER - TY - JOUR AU - Eurich, D. T. AU - Weir, D. L. AU - Majumdar, S. R. AU - Tsuyuki, R. T. AU - Johnson, J. A. AU - Tjosvold, L. PY - 2013 DA - 2013// TI - Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: systematic review of observational studies involving 34,000 patients JO - Circ Heart Fail VL - 6 UR - https://doi.org/10.1161/CIRCHEARTFAILURE.112.000162 DO - 10.1161/CIRCHEARTFAILURE.112.000162 ID - Eurich2013 ER - TY - JOUR AU - Christiansen, C. F. AU - Johansen, M. B. AU - Christensen, S. AU - O Brien, J. M. AU - Tønnesen, E. AU - Sørensen, H. T. PY - 2013 DA - 2013// TI - Preadmission metformin use and mortality among intensive care patients with diabetes: a cohort study JO - Crit Care VL - 17 UR - https://doi.org/10.1186/cc12886 DO - 10.1186/cc12886 ID - Christiansen2013 ER - TY - JOUR AU - Arroyo, D. AU - Melero, R. AU - Panizo, N. AU - Goicoechea, M. AU - Rodríguez-Benítez, P. AU - Vinuesa, S. G. PY - 2011 DA - 2011// TI - Metformin-associated acute kidney injury and lactic acidosis JO - Int J Nephrol. VL - 2011 UR - https://doi.org/10.4061/2011/749653 DO - 10.4061/2011/749653 ID - Arroyo2011 ER - TY - JOUR AU - Salpeter, S. R. AU - Greyber, E. AU - Pasternak, G. A. AU - Salpeter, E. E. PY - 2010 DA - 2010// TI - Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus JO - Cochrane Database Syst Rev. VL - 4 ID - Salpeter2010 ER - TY - JOUR AU - Cicero, A. F. G. AU - Tartagni, E. AU - Ertek, S. PY - 2012 DA - 2012// TI - Metformin and its clinical use: new insights for an old drug in clinical practice JO - Arch Med Sci. VL - 8 UR - https://doi.org/10.5114/aoms.2012.31622 DO - 10.5114/aoms.2012.31622 ID - Cicero2012 ER - TY - JOUR AU - Kjelland, C. B. AU - Djogovic, D. PY - 2010 DA - 2010// TI - The role of serum lactate in the acute care setting JO - J Intensive Care Med. VL - 25 UR - https://doi.org/10.1177/0885066610371191 DO - 10.1177/0885066610371191 ID - Kjelland2010 ER - TY - JOUR AU - Rishu, A. H. AU - Khan, R. AU - Al-Dorzi, H. M. AU - Tamim, H. M. AU - Al-Qahtani, S. AU - Al-Ghamdi, G. PY - 2013 DA - 2013// TI - Even mild hyperlactatemia is associated with increased mortality in critically ill patients JO - Crit Care VL - 17 UR - https://doi.org/10.1186/cc12891 DO - 10.1186/cc12891 ID - Rishu2013 ER - TY - JOUR AU - Dellinger, R. P. AU - Levy, M. M. AU - Rhodes, A. AU - Annane, D. AU - Gerlach, H. AU - Opal, S. M. PY - 2013 DA - 2013// TI - Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012 JO - Intensive Care Med VL - 39 UR - https://doi.org/10.1007/s00134-012-2769-8 DO - 10.1007/s00134-012-2769-8 ID - Dellinger2013 ER - TY - JOUR PY - 2012 DA - 2012// TI - KDIGO clinical practice guideline for acute kidney injury JO - Kidney Int Suppl VL - 2 UR - https://doi.org/10.1038/kisup.2012.1 DO - 10.1038/kisup.2012.1 ID - ref10 ER - TY - JOUR AU - Romero, S. P. AU - Andrey, J. L. AU - Garcia-Egido, A. AU - Escobar, M. A. AU - Perez, V. AU - Corzo, R. PY - 2013 DA - 2013// TI - Metformin therapy and prognosis of patients with heart failure and new-onset diabetes mellitus. A propensity-matched study in the community JO - Int J Cardiol VL - 166 UR - https://doi.org/10.1016/j.ijcard.2011.10.141 DO - 10.1016/j.ijcard.2011.10.141 ID - Romero2013 ER - TY - JOUR AU - Zhang, X. AU - Harmsen, W. S. AU - Mettler, T. A. AU - Kim, W. R. AU - Roberts, R. O. AU - Therneau, T. M. PY - 2014 DA - 2014// TI - Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes JO - Hepatology VL - 60 UR - https://doi.org/10.1002/hep.27199 DO - 10.1002/hep.27199 ID - Zhang2014 ER - TY - JOUR AU - Harris, K. AU - Smith, L. PY - 2013 DA - 2013// TI - Safety and efficacy of metformin in patients with type 2 diabetes mellitus and chronic hepatitis C JO - Ann Pharmacother VL - 47 UR - https://doi.org/10.1177/1060028013503108 DO - 10.1177/1060028013503108 ID - Harris2013 ER - TY - JOUR AU - Inzucchi, S. E. AU - Lipska, K. J. AU - Mayo, H. AU - Bailey, C. J. AU - McGuire, D. K. PY - 2014 DA - 2014// TI - Metformin in patients with type 2 diabetes and kidney disease: a systematic review JO - JAMA VL - 312 UR - https://doi.org/10.1001/jama.2014.15298 DO - 10.1001/jama.2014.15298 ID - Inzucchi2014 ER - TY - JOUR AU - Chang, C. -. H. AU - Sakaguchi, M. AU - Dolin, P. PY - 2016 DA - 2016// TI - Epidemiology of lactic acidosis in type 2 diabetes patients with metformin in Japan JO - Pharmacoepidemiol Drug Saf VL - 25 UR - https://doi.org/10.1002/pds.4030 DO - 10.1002/pds.4030 ID - Chang2016 ER - TY - JOUR AU - Kamber, N. AU - Davis, W. A. AU - Bruce, D. G. AU - Davis, T. M. E. PY - 2008 DA - 2008// TI - Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study JO - Med J Aust VL - 188 ID - Kamber2008 ER - TY - JOUR AU - Sipahi, S. AU - Solak, Y. AU - Acikgoz, S. B. AU - Genc, A. B. AU - Yildirim, M. AU - Yilmaz, U. PY - 2016 DA - 2016// TI - Retrospective analysis of lactic acidosis-related parameters upon and after metformin discontinuation in patients with diabetes and chronic kidney disease JO - Int Urol Nephrol VL - 48 UR - https://doi.org/10.1007/s11255-016-1288-x DO - 10.1007/s11255-016-1288-x ID - Sipahi2016 ER - TY - JOUR AU - Cucchiari, D. AU - Podestà, M. A. AU - Merizzoli, E. AU - Calvetta, A. AU - Morenghi, E. AU - Angelini, C. PY - 2016 DA - 2016// TI - Dose-related effects of metformin on acid-base balance and renal function in patients with diabetes who develop acute renal failure: a cross-sectional study JO - Acta Diabetol VL - 53 UR - https://doi.org/10.1007/s00592-016-0836-2 DO - 10.1007/s00592-016-0836-2 ID - Cucchiari2016 ER - TY - JOUR AU - DeFronzo, R. AU - Fleming, G. A. AU - Chen, K. AU - Bicsak, T. A. PY - 2016 DA - 2016// TI - Metformin-associated lactic acidosis: current perspectives on causes and risk JO - Metabolism VL - 65 UR - https://doi.org/10.1016/j.metabol.2015.10.014 DO - 10.1016/j.metabol.2015.10.014 ID - DeFronzo2016 ER - TY - JOUR AU - Hitchings, A. W. AU - Archer, J. R. H. AU - Srivastava, S. A. AU - Baker, E. H. PY - 2015 DA - 2015// TI - Safety of metformin in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus JO - COPD VL - 12 UR - https://doi.org/10.3109/15412555.2014.898052 DO - 10.3109/15412555.2014.898052 ID - Hitchings2015 ER - TY - JOUR AU - Adam, W. R. AU - O’Brien, R. C. PY - 2014 DA - 2014// TI - A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure JO - Diabet Med J Br Diabet Assoc VL - 31 UR - https://doi.org/10.1111/dme.12515 DO - 10.1111/dme.12515 ID - Adam2014 ER - TY - JOUR AU - Piel, S. AU - Ehinger, J. K. AU - Elmér, E. AU - Hansson, M. J. PY - 2015 DA - 2015// TI - Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition JO - Acta Physiol Oxf Engl VL - 213 UR - https://doi.org/10.1111/apha.12311 DO - 10.1111/apha.12311 ID - Piel2015 ER - TY - JOUR AU - Protti, A. AU - Lecchi, A. AU - Fortunato, F. AU - Artoni, A. AU - Greppi, N. AU - Vecchio, S. PY - 2012 DA - 2012// TI - Metformin overdose causes platelet mitochondrial dysfunction in humans JO - Crit Care VL - 16 UR - https://doi.org/10.1186/cc11663 DO - 10.1186/cc11663 ID - Protti2012 ER - TY - JOUR AU - Protti, A. AU - Fortunato, F. AU - Monti, M. AU - Vecchio, S. AU - Gatti, S. AU - Comi, G. P. PY - 2012 DA - 2012// TI - Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs JO - Crit Care VL - 16 UR - https://doi.org/10.1186/cc11332 DO - 10.1186/cc11332 ID - Protti2012 ER - TY - JOUR AU - Protti, A. AU - Russo, R. AU - Tagliabue, P. AU - Vecchio, S. AU - Singer, M. AU - Rudiger, A. PY - 2010 DA - 2010// TI - Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication JO - Crit Care VL - 14 UR - https://doi.org/10.1186/cc8885 DO - 10.1186/cc8885 ID - Protti2010 ER - TY - JOUR AU - Liu, F. AU - Lu, J. AU - Tang, J. AU - Li, L. AU - Lu, H. AU - Hou, X. PY - 2009 DA - 2009// TI - Relationship of plasma creatinine and lactic acid in type 2 diabetic patients without renal dysfunction JO - Chin Med J (Engl) VL - 122 ID - Liu2009 ER - TY - JOUR AU - Dykens, J. A. AU - Jamieson, J. AU - Marroquin, L. AU - Nadanaciva, S. AU - Billis, P. A. AU - Will, Y. PY - 2008 DA - 2008// TI - Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro JO - Toxicol Appl Pharmacol VL - 233 UR - https://doi.org/10.1016/j.taap.2008.08.013 DO - 10.1016/j.taap.2008.08.013 ID - Dykens2008 ER - TY - JOUR AU - Filho, R. R. AU - Rocha, L. L. AU - Corrêa, T. D. AU - Pessoa, C. M. S. AU - Colombo, G. AU - Assuncao, M. S. C. PY - 2016 DA - 2016// TI - Blood lactate levels cutoff and mortality prediction in sepsis-time for a reappraisal? A retrospective cohort study JO - Shock VL - 46 UR - https://doi.org/10.1097/SHK.0000000000000667 DO - 10.1097/SHK.0000000000000667 ID - Filho2016 ER - TY - JOUR AU - Lepelley, M. AU - Giai, J. AU - Yahiaoui, N. AU - Chanoine, S. AU - Villier, C. PY - 2016 DA - 2016// TI - Lactic acidosis in diabetic population: is metformin implicated? Results of a matched case-control study performed on the type 2 diabetes population of Grenoble Hospital University JO - J Diabetes Res VL - 2016 UR - https://doi.org/10.1155/2016/3545914 DO - 10.1155/2016/3545914 ID - Lepelley2016 ER - TY - JOUR AU - Eppenga, W. L. AU - Lalmohamed, A. AU - Geerts, A. F. AU - Derijks, H. J. AU - Wensing, M. AU - Egberts, A. PY - 2014 DA - 2014// TI - Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study JO - Diabetes Care VL - 37 UR - https://doi.org/10.2337/dc13-3023 DO - 10.2337/dc13-3023 ID - Eppenga2014 ER - TY - JOUR AU - Duong, J. K. AU - Furlong, T. J. AU - Roberts, D. M. AU - Graham, G. G. AU - Greenfield, J. R. AU - Williams, K. M. PY - 2013 DA - 2013// TI - The role of metformin in metformin-associated lactic acidosis (MALA): case series and formulation of a model of pathogenesis JO - Drug Saf VL - 36 UR - https://doi.org/10.1007/s40264-013-0038-6 DO - 10.1007/s40264-013-0038-6 ID - Duong2013 ER - TY - JOUR AU - Miller, R. A. AU - Chu, Q. AU - Xie, J. AU - Foretz, M. AU - Viollet, B. AU - Birnbaum, M. J. PY - 2013 DA - 2013// TI - Biguanides suppress hepatic glucagon signaling by decreasing production of cyclic AMP JO - Nature VL - 494 UR - https://doi.org/10.1038/nature11808 DO - 10.1038/nature11808 ID - Miller2013 ER - TY - JOUR AU - Hung, S. -. C. AU - Chang, Y. -. K. AU - Liu, J. -. S. AU - Kuo, K. -. L. AU - Chen, Y. -. H. AU - Hsu, C. -. C. PY - 2015 DA - 2015// TI - Metformin use and mortality in patients with advanced chronic kidney disease: national, retrospective, observational, cohort study JO - Lancet Diabetes Endocrinol VL - 3 UR - https://doi.org/10.1016/S2213-8587(15)00123-0 DO - 10.1016/S2213-8587(15)00123-0 ID - Hung2015 ER -