Table 1 Cohort of ICU diabetics: main characteristics at ICU admission, during ICU stay and ICU/hospital outcome
ICU diabetics | No metformin | Metformin | |
|---|---|---|---|
N | 635 | 395 (62.2) | 240 (37.8) |
Age (y) | 71 [61–79] | 73 [62.5–80] | 68 [60–78]* |
Men | 408 (64.3) | 255 (64.6) | 153 (63.8) |
SAPS II | 39 [31-52] | 40 [32-52] | 38 [29-51] |
Usual metformin contraindication | 387 (60.9) | 268 (67.9) | 119 (49.6)* |
Chronic respiratory insufficiency | 190 (29.9) | 132 (33.4) | 58 (24.2)* |
Chronic cardiac insufficiency | 138 (21.7) | 92 (23.3) | 46 (19.2) |
Chronic liver disease | 75 (11.8) | 49 (12.4) | 26 (10.8) |
Chronic kidney failure | 144 (22.7) | 128 (32.4) | 16 (6.7)* |
Recent myocardial infarction | 8 (1.3) | 5 (1.3) | 3 (1.3) |
pH | 7.36 [7.28–7.42] | 7.36 [7.29–7.43] | 7.36 [7.27–7.42] |
PaCO2 (mmHg) | 36 [29–43] | 37 [30–44] | 36 [28–43] |
HCO3 (mmHg) | 21.3 [17–25.2] | 21.9 [17.5–26] | 20.4 [15.3–24]* |
Lactate (mmol/L) | 1.4 [0.9–2.4] | 1.2 [0.8–2.1] | 1.8 [1.1–3.9]* |
INR | 1.25 [1.06–1.71] | 1.26 [1.06–1.65] | 1.24 [1.07–1.77] |
Bilirubin (µmol/L) | 10 [7–16] | 10 [7–16] | 10 [7–16] |
C-reactive protein (mg/L) | 34 [8–115] | 35 [8–115] | 32 [8–115] |
Haemoglobin (g/dL) | 11.2 [9.6–13] | 11.1 [9.6–12.7] | 11.7 [9.7–13.4] |
Leucocytes (G/L) | 11.2 [8.1–15.3] | 10.8 [7.5–14.6] | 11.7 [8.4–16.3] |
Platelets (G/L) | 213 [155–277] | 207 [155–271] | 219 [157–293] |
Creatinine (µmol/L) | 131 [85–238] | 153 [90–285] | 108 [80–174]* |
Acute kidney injury | 392 (61.7) | 268 (67.8) | 124 (51.7)* |
Renal replacement therapy | 113 (17.8) | 72 (18.2) | 41 (17.1) |
Vasopressors | 229 (36.1) | 136 (34.4) | 93 (38.8) |
Invasive ventilation | 230 (36.2) | 139 (35.2) | 91 (37.9) |
ICU length of stay (d) | 6 [3–10] | 6 [3.5–10] | 6 [3–9] |
ICU death | 117 (18.4) | 75 (19) | 42 (17.5) |
Hospital length of stay (d) | 12 [6–23] | 12 [6–23] | 13 [7–23] |
Hospital death | 140 (22) | 92 (23.3) | 48 (20) |