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Table 3 Hospital death among septic shock patients: univariate analysis and conditional forward stepwise multivariate analysis with metformin as analysis factor

From: Does metformin exposure before ICU stay have any impact on patients’ outcome? A retrospective cohort study of diabetic patients

 

Survivor

Non-survivor

P-univariate

Odds ratio

P-multivariate

N

80 (61.1)

51 (38.9)

Men

49 (61.3)

40 (78.4)

0.055

NS

NS

SAPS II

49 [40–61]

65 [46–80]

0.001

1.05 (1.04–1.07)

< 0.001

Metformin (n)

32 (40)

20 (39.2)

1

0.61 (0.37–0.99)

0.049

Lactate (mmol/L)

1.7 [1–3.9]

3.2 [1.4–7.1]

0.003

1.21 (1.1–1.34)

< 0.001

ARDS (n)

23 (28.8)

25 (49)

0.03

NS

NS

RRT (n)

24 (30)

27 (52.9)

0.011

NS

NS

Invasive ventilation (n)

48 (60)

48 (94.1)

< 0.001

NS

NS

Urinary output day 1 (mL)

1400 [675–2400]

1030 [65–1900]

0.03

NS

NS

  1. α = 0.05. Area under the curve of the multivariate model = 0.786
  2. RRT renal replacement therapy, NS not significant