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Table 2 Summary of findings for the effect of procalcitonin-guided strategy on predefined outcomes in intensive care unit patients

From: Procalcitonin-guided antibiotic therapy in intensive care unit patients: a systematic review and meta-analysis

PCT-guided strategy Predefined outcome Number of trials N Estimated benefit with antibiotic I 2 (%) P value
ABT discontinuation Duration of antibiotic use 8 3404 − 1.66 days (− 2.36, − 0.96) 71 P < 0.0001
Antibiotic-free days 4 2120 2.26 days (1.40, 3.12) 0 P < 0.0001
Short-term mortality 8 3414 0.86 (0.76, 0.98) 0 0.02
Length of stay in ICU 7 3326 − 0.00 days (− 0.58, 0.58) 0 0.99
Length of stay in hospital 6 3290 0.43 days (− 0.83, 1.70) 30 0.50
ABT initiation Duration of antibiotic use
Antibiotic-free days
Short-term mortality 3 1040 1.01 (0.84, 1.23) 0 0.90
Length of stay in ICU 2 581 − 1.22 days (− 4.34, 1.90) 60 0.44
Length of stay in hospital
ABT initiation and discontinuation Duration of antibiotic use 2 679 − 1.90 days (− 5.62, 1.83) 96 0.32
Antibiotic-free days 2 679 1.31 days (− 1.34, 3.95) 90 0.33
Short-term mortality 2 682 1.10 (0.86, 1.39) 30 0.46
Length of stay in ICU 2 682 − 1.45 days (− 0.91, 3.80) 0 0.23
Length of stay in hospital 2 750 − 0.43 days (− 3.36, 2.49) 0 0.77
  1. ABT antibiotics, PCT procalcitonin, ICU intensive care unit