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Annals of Intensive Care
Fig. 3 | Annals of Intensive Care

Fig. 3

From: Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats

Fig. 3

Histological lung injury. Lung sections were stained with hematoxylin–eosin to assess tissue histological injuries. Lung histologic changes were graded on a scale of 0–4 (0: absent/appears normal; 1: light; 2: moderate; 3: strong; 4: intense) for congestion, edema, inflammation and hemorrhage. a Total score was the sum of the four parameters (0–16 points for each slide). b Leukocyte infiltration is also represented for each group. c Lung section representative of CLP–NaCl and (D) CLP–TM groups. Leukocyte infiltration is significantly decreased in lung sections from CLP–TM rats compared to CLP–NaCl rats, leading to a decreased global lung injury score (a). n = 10 per subset. Results are expressed in mean ± SD. *p < 0.05 versus sham–NaCl group and # p < 0.05 versus CLP–NaCl group

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