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Table 1 Cell origin of microvesicles emitted by septic and control rats

From: Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats

  Sham–NaCl Sham–TM CLP–NaCl CLP–TM
MVs (nM Eq PhtdSer)
 Annexin-A5+ MVs 6.2 ± 4.4 9.1 ± 1.7b 29.5 ± 4.2a 17.3 ± 1.8b
 CD45+ MVs/leukocytes 0.10 ± 0.08 0.07 ± 0.09b 1.8 ± 0.64a 0.60 ± 0.51b
 CD54+ MVs 0.69 ± 0.43 1.0 ± 0.36 2.7 ± 1.0a 8.4 ± 2.6a
 CD61+ MVs/platelets 0.18 ± 0.10 0.50 ± 0.14 1.0 ± 0.31a 0.88 ± 0.18a
  1. Septic and control (sham–NaCl and sham–TM) rats were treated by rhTM or 0.9% sodium chloride. Data are expressed as mean ± SD. p < 0.05
  2. CLP cecal ligation and puncture, MVs microvesicles, PhtdSer phosphatidylserine, rhTM recombinant human thrombomodulin. n = 10 for each subset
  3. avs. sham–NaCl
  4. bvs. CLP–NaCl
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