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Table 1 Cell origin of microvesicles emitted by septic and control rats

From: Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats

 

Sham–NaCl

Sham–TM

CLP–NaCl

CLP–TM

MVs (nM Eq PhtdSer)

 Annexin-A5+ MVs

6.2 ± 4.4

9.1 ± 1.7b

29.5 ± 4.2a

17.3 ± 1.8b

 CD45+ MVs/leukocytes

0.10 ± 0.08

0.07 ± 0.09b

1.8 ± 0.64a

0.60 ± 0.51b

 CD54+ MVs

0.69 ± 0.43

1.0 ± 0.36

2.7 ± 1.0a

8.4 ± 2.6a

 CD61+ MVs/platelets

0.18 ± 0.10

0.50 ± 0.14

1.0 ± 0.31a

0.88 ± 0.18a

  1. Septic and control (sham–NaCl and sham–TM) rats were treated by rhTM or 0.9% sodium chloride. Data are expressed as mean ± SD. p < 0.05
  2. CLP cecal ligation and puncture, MVs microvesicles, PhtdSer phosphatidylserine, rhTM recombinant human thrombomodulin. n = 10 for each subset
  3. avs. sham–NaCl
  4. bvs. CLP–NaCl