Skip to main content
Annals of Intensive Care

Table 3 Risk factors at ICU admission for bleeding in unadjusted and adjusted analyses

From: Risks of bleeding and thrombosis in intensive care unit patients with haematological malignancies

Unadjusted analyses

Bleeding within 5 days of admission

Bleeding in ICUa

No. (%)

OR (95% CI)

p value

No. (%)

OR (95% CI)

p value

Acute lymphatic leukaemia

5 (36)

1.37 (0.43–4.36)

0.60

7 (50)

1.37 (0.44–4.20)

0.58

Acute myeloid leukaemia

33 (44)

0.82 (0.38–1.77)

0.82

45 (60)

0.70 (0.33–1.51)

0.36

Myelodysplastic syndrome

11 (40)

1.08 (0.45–2.60)

0.85

14 (52)

1.31 (0.55–3.10)

0.55

Recent chemotherapyb

39 (51)

3.16 (1.36–7.36)

0.006

49 (64)

2.45 (1.12–5.37)

0.02

HSCT

15 (35)

0.61 (0.28–1.33)

0.22

24 (56)

0.93 (0.44–2.00)

0.86

Leukopenia at admissionc

31 (56)

3.09 (1.43–6.64)

0.004

35 (64)

1.69 (0.80–3.56)

0.16

Fungal infectiond

10 (48)

1.31 (0.51–3.37)

0.58

14 (67)

1.65 (0.61–4.47)

0.32

Renal replacement therapy

11 (48)

1.33 (0.53–3.32)

0.54

13 (57)

0.98 (0.39–2.46)

0.97

Mechanical ventilatione

28 (41)

0.90 (0.43–1.90)

0.78

39 (57)

1.05 (0.50–2.21)

0.91

Use of LMWHf

9 (29)

0.49 (0.19–1.19)

0.11

16 (52)

0.81 (0.35–1.86)

0.62

 

Median (IQR)

OR (95% CI)

p value

Median (IQR)

OR (95% CI)

p value

Age

58 (48–65)

1.00 (0.97–1.03)

0.73

59 (45–66)

1.00 (0.95–1.03)

0.97

Platelet count at admission

22 (15–31)

1.16 (1.03–1.32) f

0.001

24 (15–35)

1.14 (1.03–1.26) f

0.004

SOFA-score at admission

12 (9–14)

1.05 (0.96–1.15)

0.14

12(9–14)

1.03 (0.95–1.13)

0.34

Adjusted analysesg

Bleeding within 5 days

Bleeding in ICU

Median(IQR)

OR (95%CI)

p value

Median (IQR)

OR (95% CI)

p value

Recent chemotherapy

n/a

2.27 (0.93–5.56)

0.07

n/a

1.70 (0.70–3.95)

0.24

White blood cell count

2.8 (0.2–11)

1.01 (0.99–1.02)

0.39

1.2 (0.1–8.5)

1.02 (1.00–1.04)

0.07

Platelet counth

22 (15–31)

1.15 (1.00–1.33)

0.058

24 (15–35)

1.18 (1.03–1.35)

0.016

  1. Bold indicates significant results (p < 0.05)
  2. n/a not applicable
  3. aOne patient lost at 1-year follow up
  4. bChemotherapy within 6 weeks of ICU-admission
  5. cLeukopenia at ICU admission defined as white blood cell (WBC) count < 2 (missing data = 1)
  6. dConfirmed systemic or respiratory fungal infection
  7. eMechanical ventilation on day one in ICU
  8. fLow molecular weight heparin (enoxaparin 20–40 mg daily)
  9. gLogistic regression analysis with bleeding as outcome and chemotherapy, WBC count and platelet count as co-variates
  10. hPlatelet count OR for every decrease in platelet count by 10 × 109 (at admission)
Back to article page