Frequency and prognostic impact of basic critical care echocardiography abnormalities in patients with acute respiratory distress syndrome

Annals of Intensive Care

Table 2 Hospital mortality of patients with acute respiratory distress syndrome, with or without severe acute cor pulmonale

Hospital mortality	All ARDS patients (N = 234)	ARDS patients without severe ACP (N = 168)	ARDS patients with severe ACP (N = 66)	P value^b
Severity of ARDS^a (%, CI)
Mild	17/83 (20.5, 12.4–30.8)	10/59 (17.0, 8.4–29.0)	7/24 (29.2, 12.6–51.1)	0.239
Moderate	36/108 (33.3, 24.6–43.1)	22/79 (27.9, 18.3–39.1)	14/29 (48.3, 29.4–67.5)	0.065
Severe	22/43 (51.2, 35.5–66.7)	15/30 (50.0, 31.3–68.7)	7/13 (53.8, 25.1–80.8)	1.000
Overall cohort (%, CI)	75/234 (32.1, 26.1–38.4)	47/168 (28.0, 21.3–35.4)	28/66 (42.4, 30.3–55.2)	0.043*

ACP Acute cor pulmonale (severe ACP is defined as right ventricular dilatation with the right-to-left ventricular size ratio ≥ 1 in end diastole at the papillary muscle level and interventricular septal straightening/paradoxical motion), ARDS acute respiratory distress syndrome, CI 95% confidence interval
*P < 0.05
^aARDS severity according to the Berlin Definition: mild (PF ratio 201–300 mmHg), moderate (PF ratio 101–200 mmHg) and severe (PF ratio 100 mmHg or less), where PF ratio is the ratio of arterial oxygen partial pressure (mmHg) to inspired oxygen fraction
^bComputed for the mortality difference between patients with and without severe acute cor pulmonale, using the Fisher exact test