Table 1 Characteristics of 130 patients with known or de novo SVV (small-vessel vasculitis) admitted to the intensive care unit for Acute Respiratory Failure (ARF)

Demographics

Age, year

64 [51–75.5]

59 [44–72]

68 [59–76]

0.004

Male gender, n (%)

82 (63)

38 (57)

44 (70)

0.15

Cardiovascular disease^a, n (%)

77 (59)

30 (45)

47 (75)

0.0007

Respiratory disease^b, n (%)

60 (46)

18 (27)

42 (67)

< 0.0001

Immunosuppression^c, n (%)

62 (48)

11 (16)

51 (81)

< 0.0001

Chronic renal disease, n (%)

29 (22)

4 (6)

25 (40)

< 0.0002

Chronic dialysis, n (%)

17 (13)

1 (1)

16 (25)

< 0.0003

Small Vessels Vasculitis (SVV)

Granulomatosis with Polyangiitis (Wegener’s), n (%)

53 (41)

27 (40)

26 (41)

1

Microscopic Polyangiitis, n (%)

41 (32)

25 (37)

16 (25)

0.19

Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss vasculitis), n (%)

23 (18)

8 (12)

15 (24)

0.11

Goodpasture, n (%)

11 (8)

7 (10)

4 (6)

0.53

Others, n (%)

2 (2)

0 (0)

2 (3)

0.23

Time from SVV diagnosis to ICU admission, months

3 [0–60]

0 [0–0]

48 [5–132]

< 0.0001

BVAS (Birmingham Vasculitis Activity Score)

13 [0–21]

21 [15–25]

0 [0–6]

< 0.0001

FFS (Five factor score)

1 [0–2]

1 [0–2]

0 [0–1]

0.0002

Reasons to ICU admission in addition to ARF, n (%)

Shock

22 (17)

7 (10)

15 (24)

0.06

Neurological

20 (15)

7 (10)

13 (21)

0.14

Cardiac arrest

6 (5)

3 (4)

3 (5)

Ns

Time (days) between first respiratory symptoms and ICU admission, n (%)

<3 days

50 (38)

15 (22)

35 (56)

< 0.0001

3–10 days

31 (24)

18 (27)

13 (21)

0.42

>10 days

49 (38)

34 (51)

15 (24)

0.002

Extra respiratory symptoms ^d on ICU admission, n (%)

111 (85)

60 (90)

51 (81)

0.22

Specific extra respiratory symptoms ^e on ICU admission, n (%)

65 (50)

48 (72)

17 (27)

< 0.0001

Severity criteria on ICU admission

SAPS II

39 [28–54]

37 [22–48]

45 [30–58]

0.009

SOFA

6 [4–8]

6 [3–8]

6 [4–9]

0.44