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Table 2 Blood parameters, coagulation parameters and anticoagulation in the two groups during the study period

From: Thromboelastography-based anticoagulation management during extracorporeal membrane oxygenation: a safety and feasibility pilot study

Parameters TEG group (N = 21) aPTT group (N = 21) P value*
Hemoglobin (g/dL) 10.0 (9.5–10.6) 10.2 (9.7–10.8) 0.25
Hematocrit (%) 30.5 (28.5–31.9) 30.8 (29.0–32.4) 0.47
Platelet count (*109/L) 118.0 (72–202) 122 (88–172) 0.78
Creatinine (mg/dL) 0.6 (0.4–1.1) 1.0 (0.8–1.3) 0.14
Heparin§ (IU/kg/h) 11.7 (9.5–15.3) 15.7 (10.9–21.3) 0.03
aPTT (ratio) 1.2 (1.1–1.6) 1.6 (1.4–1.8) < 0.001
R-K° (min) 18.8 (12.9–27.4) 61.9 (32.7–90.0) < 0.001
Flat-line TEG, N (%) 34 (4.7) 52 (37.7) < 0.001
R-KH (min) 6.2 (5.2–7.6) 8.1 (6.8–9.9) 0.50
Anti-Xa (IU/mL) 0.1 (0.1–0.2) 0.3 (0.2–0.4) < 0.001
PT (ratio) 1.1 (1.1–1.3) 1.2 (1.1–1.3) 0.69
Antithrombin (%) 90.0 (71.0–103.0) 77.0 (64.0–91.0) 0.15
Antithrombin (IU/die) 1000 (0–2000) 2000 (2000–2000) 0.17
Fibrinogen (mg/dL) 391.5 (275.0–524.5) 466.0 (327.0–611.0) 0.96
Free hemoglobin (mg/dL) 8.5 (6.7–10.4) 9.1 (7.0–12.7) 0.50
CRP (mg/dL) 12.5 (7.6–23.0) 15.3 (7.8–23.2) 0.52
  1. Data are reported as median (25th–75th percentile) or as absolute and relative frequencies as appropriate
  2. Heparin and antithrombin were administered i.v. as continuous infusion
  3. N number of measurements, PT prothrombin time, aPTT activated partial thromboplastin time, CRP C-reactive protein
  4. *From random intercept linear regression models
  5. §The amount of heparin infused to each patient was calculated as the total administered heparin per kg of body weight (including boluses) divided by the total hours of heparin infusion. P value from Wilcoxon rank-sum test
  6. °R-K was arbitrarily considered equal to 90 if unable to generate a value within 90 min (flat-line)