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Annals of Intensive Care

Table 2 Characteristics of patients with HH classified by ASTmax subgroup

From: Epidemiology, causes, evolution and outcome in a single-center cohort of 1116 critically ill patients with hypoxic hepatitis

Variable

Patients

Variable

Patients

ASTmax subgroup

P

ASTmax subgroup

P

5× ULN–10× ULN (n = 395)

10× ULN–20× ULN (n = 261)

> 20× ULN (n = 460)

5× ULN–10× ULN (n = 395)

10× ULN–20× ULN (n = 261)

> 20× ULN (n = 460)

Sexa

    

SOI scoresc

    

 Male

60.5% (239)

62.5% (163)

61.3% (282)

0.882

 APS-IIb

24.0 (18.0–31.0)

26.5 (20.0–32.2)

32.0 (24.0–37.9)

< 0.001

Ageb (year)

63.0 (45.0–73.5)

66.0 (56.0–75.0)

67.0 (55.8–75.0)

0.014

 SAPS-IIb

57.0 (36.2–74.0)

60.0 (41.0–78.2)

73.0 (56.0–86.5)

< 0.001

BMIb (kg/m2)

25.5 (23.1–28.7)

25.5 (22.9–29.2)

25.1 (22.9–28.9)

0.647

Supportive therapyc

    

Causea

    

 Ventilationa

71.9% (284)

72.4% (189)

78.9% (363)

0.035

 Overall

   

0.135

 Medication

    

 Cardiac failure

50.6% (200)

49.8% (130)

47.4% (218)

–

  Inotropic agentsa

38.5% (152)

37.9% (99)

50.2% (231)

< 0.001

 Septic shock

29.4% (116)

26.1% (68)

32.4% (149)

–

  Vasopressor agentsa

50.9% (201)

59.4% (155)

70.0% (322)

< 0.001

 Hypovolemic shock

7.6% (30)

10.3% (27)

10.4% (48)

–

 Dialysisa

4.8% (19)

8.4% (22)

14.1% (65)

< 0.001

 Acute respiratory failure

7.1% (28)

9.2% (24)

4.1% (19)

–

 IABPa

13.7% (54)

20.7% (54)

18.9% (87)

0.041

 Acute on chronic respiratory failure

3.3% (13)

1.9% (5)

4.1% (19)

–

LOS

    

 Pulmonary embolism

1.5% (6)

1.5% (4)

1.3% (6)

–

 ICUb (day)

4.6 (1.6–11.2)

4.8 (1.4–11.2)

4.0 (0.7–12.4)

0.325

 Hyperthermia

0.5% (2)

1.1% (3)

0.2% (1)

–

 Hospitalb (day)

12.5 (6.5–29.5)

13.1 (4.1–27.6)

10.2 (0.9–29.8)

0.250

Comorbidities

    

Duration

    

 Echocardioa

    

 Episode of HHb (h)

23.6 (11.4–37.2)

56.8 (40.5–79.6)

104.7 (78.1–132.0)

< 0.001

  Normal

43.8% (173)

34.5% (90)

39.8% (183)

0.234

 Recovery of HHb (h)

12.6 (6.1–22.2)

36.2 (22.7–52.0)

77.7 (56.6–102.4)

< 0.001

  LV dysfunction

20.5% (81)

27.6% (72)

27.1% (136)

0.136

28-day mortality

    

  Missing

25.3% (100)

26.8% (70)

17.0% (78)

0.008

 ICUa

29.4% (116)

38.3% (100)

52.0% (239)

< 0.001

  LV and RV dysfunction

5.8% (23)

8.4% (22)

9.6% (44)

0.452

 In-hospitala

33.2% (131)

44.4% (116)

55.4% (255)

< 0.001

  RV dysfunction

4.6% (18)

2.7% (7)

6.1% (28)

0.422

     

 DMa

14.9% (59)

21.1% (55)

20.7% (95)

0.055

     

 Chronic respiratory failurea

12.2% (48)

10.7% (28)

11.1% (51)

0.826

     
  1. APS-II acute physiology II, AST aspartate aminotransferase, ASTmax maximum AST value, BMI body mass index, HH hypoxic hepatitis, IABP intra-aortic balloon pump, ICU intensive care unit, LOS length of stay, LV left ventricle, P P value, Q1 first quartile, Q3 third quartile, RV right ventricle, SAPS-II simplified acute physiology II, SOI severity of illness, T-ASTmax time point of maximum AST value, ULN upper limit of normal
  2. Italics indicate the significant P values
  3. a% (n)
  4. bMedian (Q1–Q3)
  5. cAt T-ASTmax ± 12 h
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