Fluid therapy and outcome: a prospective observational study in 65 German intensive care units between 2010 and 2011

Ertmer, Christian; Zwißler, Bernhard; Van Aken, Hugo; Christ, Michael; Spöhr, Fabian; Schneider, Axel; Deisz, Robert; Jacob, Matthias

doi:10.1186/s13613-018-0364-z

Annals of Intensive Care

Table 1 Baseline characteristics of study patients and subcohorts

From: Fluid therapy and outcome: a prospective observational study in 65 German intensive care units between 2010 and 2011

	All patients entered into database				Only patients eligible for multivariable analysis				p value
	All fluids	Crystalloids only	Crystalloids + colloids	Crystalloids + HES 130/0.4	All Fluids	Crystalloids only	Crystalloids + colloids	Crystalloids + HES 130/0.4	Crystalloids vs. colloids (all/eligible for multivariable analysis)
N (n [%])	4545 [100]	2482 [54.6]	2063 [45.4]	1175 [25.9]	3902 [100]	1888 [48.4]	2014 [51.6]	1128 [28.9]
Age (years)	68 [55; 76]	68 [55; 76]	68 [56; 75]	68 [55; 76]	68 [55; 76]	68 [55; 76]	68 [56; 75]	68 [55;76]	0.784/0.641^b
Gender, male (n [%])	2788 [61.3]	1491 [60.1]	1297 [62.9]	761 [64.8]	2392 [61.3]	1123 [59.5]	1269 [67.2]	730 [64.7]	0.058/0.026^c
Admission type: surgical (n [%])	3223 [70.9]	1714 [69.1]	1509 [73.1]	986 [83.9]	2782 [71.3]	1316 [69.7]	1466 [72.8]	955 [84.7]	0.003/0.036^c
Cardiac surgery (n [%])	686 [15.1]	310 [12.5]	376 [18.2]	351 [29.9]	659 [16.9]	290 [15.4]	369 [18.3]	348 [30.9]	<0.001/0.015^c
Severe sepsis on admission (n [%])	394 [8.7]	184 [7.4]	210 [10.2]	71 [6.0]	370 [9.5]	163 [8.6]	207 [10.3]	71 [6.3]	0.001/0.090^c
History of CKD (n [%])	828 [18.2]	449 [18.1]	379 [18.4]	161 [13.7]	622 [15.9]	312 [16.5]	310 [16.4]	144 [12.4]	0.837/0.356^c
APACHE II	20 [14, 25]	18 [13, 23]	22 [17, 27]	24 [19, 30]	20 [14, 25]	18 [13, 23]	22 [17, 27]	24 [19, 30]	<0.001/< 0.001^b
SAPS II	21 [9; 36]	17 [7, 31]	25 [11; 41]	34 [18; 52]	21 [9; 36]	17 [8, 31]	25 [11; 41]	34 [18; 52]	<0.001/< 0.001^b
Probability of mortality [%]^a	39.0	33.3	44.7	50.7	39.1	33.1	44.7	51.0	<0.001/< 0.001^b
AKI (RIFLE “failure”) (n [%])	560 [12.3]	174 [7.0]	386 [18.7]	179 [15.2]	549 [14.1]	167 [8.8]	382 [19]	178 [15.8]	<0.001/< 0.001^c
Renal replacement therapy in ICU (n [%])	361 [7.9]	78 [3.1]	283 [13.7]	133 [11.3]	358 [9.2]	76 [4]	282 [14]	133 [11.8]	<0.001/< 0.001^c
ICU mortality (n [%])	408 [9.3]	129 [5.5]	279 [13.8]	119 [10.2]	367 [9.4]	92 [4.9]	275 [13.7]	118 [10.5]	<0.001/< 0.001^c
Length of ICU stay (days)	3 [1, 9]	2 [1, 5]	6 [3, 12]	5 [2, 11]	4 [2, 8]	2 [1, 5]	6 [3, 13]	5 [3, 11]	<0.001/< 0.001^b
90-day mortality (n [%])	707 [20.1]	284 [15.4]	423 [25.2]	191 [18.8]	613 [22.4]	198 [14.6]	415 [30.1]	187 [21.9]	<0.001/< 0.001^c

Data are given as absolute number and percentage or median [25th; 75th percentiles], as appropriate
AKI acute kidney injury, APACHE acute physiology and chronic health evaluation score, CKD chronic kidney disease, ICU intensive care unit, SAPS simplified acute physiology score
^aProbability of mortality was calculated from APACHE II and SAPS II scores as given in methods
^bWilcoxon–Mann–Whitney test
^cChi-squared contingency table test

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