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Table 2 Incidence and categorization of AKI and its association with mortality after major abdominal surgery

From: Acute kidney injury in major abdominal surgery: incidence, risk factors, pathogenesis and outcomes

Study

Design

Setting

Criteria

AKI definition

N

Incidence

Mortality

AUROC

Armstrong et al. [59]

Retrospective, single center

HBP

SCr

AKIN

1535

5.10%

1–4.0%

2–0.8%

3–0.3%

1.7% AKI versus 3.4% non-AKI, P = 0.21

NA

Bell et al. [58]

Interrupted time series analysis

MA/GI

SCr

KDIGO

3271

9.80%

NA

NA

Bihorac et al. [20]

Retrospective, single center

MA/GI

SCr

RIFLE

2337

39.3%

NA

NA

Biteker et al. [12]

Prospective, single center

MA/GI

SCr

RIFLE

510

6.7%

6.1% AKI versus 0.9% non-AKI, P = 0.003

NA

Brunelli et al. (2012)

Retrospective, single center

MA/GI

SCr

AKIN/RIFLE

1912

26.80%

NA

NA

Causey et al. [32]

Retrospective, single center

Colorectal

SCr

RIFLE

339

11.8%

6.30% AKI versus 0.9%, P = 0.065

NA

Chao et al. (2013)

Prospective, multicenter

MA/GI

SCr

AKIN

4240

23.1%

1–13.7%

2–1.8%

3–7.6%

28.40%

1–16%

2–29.7%

3–48.3% (HR 3.19, 95% CI 2.16–4.71; P < 0.001)

0.728

Cho et al. [4]

Prospective, single center

HBP

SCr, UO

AKIN

131

7.6%

1–3.8% 2–1.5%

3–2.3%

7.10% AKI versus 2.5% non-AKI, P > 0.05

NA

Coca et al. [98]

Retrospective, multicenter

Non cardiac surgery

SCr

AKIN

11.460

18.9%

1–5.2%

2–2.5%

3–1.2%

NA

NA

Correa-Gallego et al. [60]

Retrospective, single center

HBP

SCr

RIFLE

2166

15.5%

R 12.8%

I 2.3%

F 0.4%

1% AKI versus 2% non-AKI, P = 0.5

NA

Grams et al. [89]

Retrospective, single center

MA/GI

SCr

KDIGO

44.597

13.2%

1–9.4%

2–2.2%

3–1.5%

IRR 6.40 (95% CI, 5.75, 7.12) P < 0.05)

NA

Kambakamba et al. [67]

Retrospective, single center

HBP

SCr

AKIN

829

8.2%

21% AKI versus 0.3% non-AKI, P  < 0.001

0.765

Kim et al. [68]

Retrospective, single center

UGI

SCr

KDIGO

4718

14.4%

1–12.5%

2–1.3%

3–0.6%

3.8% AKI versus 0.3% non-AKI, P < 0.001 (OR, 8.75; 95% CI, 3.98–19.27; P < 0.001)

NA

Lee et al. [62]

Retrospective, single center

UGI

SCr

AKIN

595

35.3%

1–30.3%

2–2.7%

3–4.2%

4.80% AKI versus 2.1% non-AKI, P = 0.115

NA

Slankamenac et al. [64]

Retrospective, single center

HBP

SCr, UO

RIFLE

569

15.1%

22.5% AKI versus 0.8% non-AKI, P < 0.001

0.75

Sun et al. [69]

Retrospective, single center

GYN

SCr

AKIN

863

3.1%

NA

NA

Sun et al. [69]

Retrospective, single center

MA/GI

SCr

AKIN

1351

9.6%

NA

NA

Teixeira et al. [8]

Retrospective, single center

MA/GI

SCr, UO

KDIGO

450

22.4%

1–63.4%

2–19.8%

3–16.8%

20.8% AKI versus 2.3% non-AKI, P < 0.001; OR 3.7, 95% CI 1.2–11.7, P = 0.024

NA

Tomozawa et al. [65]

Retrospective, single center

HBP

SCr

AKIN

642

12.1%

1–9.8%

2–2.0%

3–0.3%

14.1% AKI versus 2.3% non-AKI, P < 0.0001

NA

Vaught et al. [9]

Retrospective, single center

GYN

SCr

RIFLE

2341

12.6%

R–7.9%

I–2.7%

F–1.9%

10% AKI versus 0.5% non-AKI, P < 0.0083

0.88

  1. GI gastrointestinal, HPB hepato-biliary, RIFLE risk, injury failure, loss, end stage, AKIN Acute Kidney Injury Network, KDIGO Kidney Disease Improving Global Outcomes, MA major abdominal, GYN gynecological, SCr serum creatinine, UO urinary output, IRR incidence rate ratio, NA not available