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Table 1 Patient characteristics by age group (years) with acute kidney injury

From: Acute kidney injury epidemiology, risk factors, and outcomes in critically ill patients 16–25 years of age treated in an adult intensive care unit

Characteristic

16–25

26–35

36–45

46–55

All

N = 862

N = 1098

N = 2189

N = 4121

N = 8270

% of age group with AKI

39.8

46.6

52.5

58.5

52.6

Age (years), Median (Q1–Q3)

22 (19–24)

31 (28–33)

41 (39–44)

51 (48–53)

45 (36–51)

Males N (%)

573 (66.5)

670 (61.2)

1304 (60)

2500 (61)

5047 (61)

Race N (%)

 White

597 (69)

790 (72)

1654 (76)

3127 (76)

6168 (76)

 Black

132 (15)

131 (12)

226 (10)

409 (10)

898 (11)

 Other

133 (15)

177 (16)

309 (14)

585 (14)

1204 (15)

Reference creatinine (mg/dl), median (Q1–Q3)

0.9 (0.7–1.1)

0.9 (0.7–1.1)

0.9 (0.7–1.1)

0.9 (0.7–1.1)

0.9 (0.7–1.1)

eGFR (ml/min/1.73 m2), median (Q1–Q3)

121.2 (92.8–133)

111.4 (81.9–123.1)

95.7 (79.4–113.9)

86.2 (76.9–104.8)

96.5 (78.6–113.2)

Fluid balance > 5%

111 (12.9)

161 (14.7)

285 (13.1)

485 (11.8)

1042 (12.6)

Cardiac disease N (%)

41 (5)

95 (9)

225 (10)

666 (16)

1027 (12)

Chronic kidney disease N (%)

16 (2)

26 (2)

135 (6)

218 (5)

395 (5)

Diabetes N (%)

50 (6)

102 (9)

227 (10)

741 (18)

1120 (14)

History of hypertension N (%)

59 (7)

135 (12)

459 (21)

1274 (31)

1927 (23)

Malignancy N (%)

7 (0.8)

15 (1)

62 (2.8)

156 (3.8)

240 (3)

Multiple comorbidities N (%)

142 (17)

290 (26)

803 (37)

1889 (46)

3124 (38)

Mechanical ventilation N (%)

580 (67)

684 (62)

1340 (61)

2413 (59)

5017 (61)

Surgical admission N (%)

504 (65)

601 (60)

1128 (57)

2216 (59)

4449 (59)

Suspected sepsis N (%)

122 (14)

198 (18)

395 (18)

698 (17)

1413 (17)

APACHE III score, median (Q1–Q3)

54 (36–72)

53 (34–73)

52 (35–74)

57 (38–80)

55 (37–76)

Vasopressor use N (%)

149 (17)

224 (20)

521 (24)

1125 (27)

2019 (24)

Moderate anemia N (%)

227 (26)

315 (29)

577 (26)

1259 (31)

2378 (29)

Maximum KDIGO N (%)

 Stage 1

400 (46)

444 (41)

738 (34)

1241 (30)

2823 (34)

 Stage 2

335 (39)

433 (39)

906 (41)

1783 (43)

3457 (42)

 Stage 3

127 (15)

221 (20)

545 (25)

1097 (27)

1990 (24)

Medication exposure N (%)

 ACE inhibitor/ARB

21(2)

27 (2)

93 (4)

269 (7)

410 (5)

 Vancomycin

124 (14)

203 (18)

373 (17)

669 (16)

1369 (17)

 Aminoglycoside

31 (3.6)

44 (4)

87 (4)

157 (4)

319 (4)

 Other Antibiotics

62 (7)

82 (7)

137 (6)

258 (6)

539 (6)

 Calcineurin inhibitor

58 (7)

94 (9)

153 (7)

264 (6)

569 (7)

 NSAID

40 (5)

90 (8)

269 (12)

716 (17)

1115 (14)

 Acyclovir

18 (2)

29 (2.6)

462 (2.1)

67 (1.6)

160 (2)

 Mannitol

28 (3)

26 (2)

32 (1.5)

30 (0.7)

116 (1)

 Phenytoin

32 (3.7)

24 (2)

47 (2)

82 (2)

185 (2)

  1. AKI acute kidney injury, eGFR estimated glomerular filtration rate, APACHE Acute Physiology and Chronic Healthy Evaluation, KDIGO Kidney Disease Improving Global Outcomes, ACE angiotensin-converting enzyme, ARB angiotensin II receptor blocker, NSAID nonsteroidal anti-inflammatory drug