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Table 1 Patient characteristics by age group (years) with acute kidney injury

From: Acute kidney injury epidemiology, risk factors, and outcomes in critically ill patients 16–25 years of age treated in an adult intensive care unit

Characteristic 16–25 26–35 36–45 46–55 All
N = 862 N = 1098 N = 2189 N = 4121 N = 8270
% of age group with AKI 39.8 46.6 52.5 58.5 52.6
Age (years), Median (Q1–Q3) 22 (19–24) 31 (28–33) 41 (39–44) 51 (48–53) 45 (36–51)
Males N (%) 573 (66.5) 670 (61.2) 1304 (60) 2500 (61) 5047 (61)
Race N (%)
 White 597 (69) 790 (72) 1654 (76) 3127 (76) 6168 (76)
 Black 132 (15) 131 (12) 226 (10) 409 (10) 898 (11)
 Other 133 (15) 177 (16) 309 (14) 585 (14) 1204 (15)
Reference creatinine (mg/dl), median (Q1–Q3) 0.9 (0.7–1.1) 0.9 (0.7–1.1) 0.9 (0.7–1.1) 0.9 (0.7–1.1) 0.9 (0.7–1.1)
eGFR (ml/min/1.73 m2), median (Q1–Q3) 121.2 (92.8–133) 111.4 (81.9–123.1) 95.7 (79.4–113.9) 86.2 (76.9–104.8) 96.5 (78.6–113.2)
Fluid balance > 5% 111 (12.9) 161 (14.7) 285 (13.1) 485 (11.8) 1042 (12.6)
Cardiac disease N (%) 41 (5) 95 (9) 225 (10) 666 (16) 1027 (12)
Chronic kidney disease N (%) 16 (2) 26 (2) 135 (6) 218 (5) 395 (5)
Diabetes N (%) 50 (6) 102 (9) 227 (10) 741 (18) 1120 (14)
History of hypertension N (%) 59 (7) 135 (12) 459 (21) 1274 (31) 1927 (23)
Malignancy N (%) 7 (0.8) 15 (1) 62 (2.8) 156 (3.8) 240 (3)
Multiple comorbidities N (%) 142 (17) 290 (26) 803 (37) 1889 (46) 3124 (38)
Mechanical ventilation N (%) 580 (67) 684 (62) 1340 (61) 2413 (59) 5017 (61)
Surgical admission N (%) 504 (65) 601 (60) 1128 (57) 2216 (59) 4449 (59)
Suspected sepsis N (%) 122 (14) 198 (18) 395 (18) 698 (17) 1413 (17)
APACHE III score, median (Q1–Q3) 54 (36–72) 53 (34–73) 52 (35–74) 57 (38–80) 55 (37–76)
Vasopressor use N (%) 149 (17) 224 (20) 521 (24) 1125 (27) 2019 (24)
Moderate anemia N (%) 227 (26) 315 (29) 577 (26) 1259 (31) 2378 (29)
Maximum KDIGO N (%)
 Stage 1 400 (46) 444 (41) 738 (34) 1241 (30) 2823 (34)
 Stage 2 335 (39) 433 (39) 906 (41) 1783 (43) 3457 (42)
 Stage 3 127 (15) 221 (20) 545 (25) 1097 (27) 1990 (24)
Medication exposure N (%)
 ACE inhibitor/ARB 21(2) 27 (2) 93 (4) 269 (7) 410 (5)
 Vancomycin 124 (14) 203 (18) 373 (17) 669 (16) 1369 (17)
 Aminoglycoside 31 (3.6) 44 (4) 87 (4) 157 (4) 319 (4)
 Other Antibiotics 62 (7) 82 (7) 137 (6) 258 (6) 539 (6)
 Calcineurin inhibitor 58 (7) 94 (9) 153 (7) 264 (6) 569 (7)
 NSAID 40 (5) 90 (8) 269 (12) 716 (17) 1115 (14)
 Acyclovir 18 (2) 29 (2.6) 462 (2.1) 67 (1.6) 160 (2)
 Mannitol 28 (3) 26 (2) 32 (1.5) 30 (0.7) 116 (1)
 Phenytoin 32 (3.7) 24 (2) 47 (2) 82 (2) 185 (2)
  1. AKI acute kidney injury, eGFR estimated glomerular filtration rate, APACHE Acute Physiology and Chronic Healthy Evaluation, KDIGO Kidney Disease Improving Global Outcomes, ACE angiotensin-converting enzyme, ARB angiotensin II receptor blocker, NSAID nonsteroidal anti-inflammatory drug