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Table 2 Multivariable logistic regression of risk factors for individuals with acute kidney injury compared to those without acute kidney injury by age categories (years)

From: Acute kidney injury epidemiology, risk factors, and outcomes in critically ill patients 16–25 years of age treated in an adult intensive care unit

Characteristic 16–25
OR (95% CI p value)
26–35
OR (95% CI p value)
36–45
OR (95% CI p value)
46–55
OR (95% CI p value)
Age per 5 years 1.39 (1.14–1.69, < 0.01) 1.21 (1.02–1.43, 0.02)
Black 1.41 (1.04–1.91, 0.02)
Other race
Diabetes 1.89 (1.09–3.29, 0.02) 1.86 (1.20–2.89, < 0.01) 1.52 (1.14–2.02, 0.01) 1.55 (1.28–1.85, 0.01)
Fluid balance > 5%
Malignancy
Hypertension
Cardiac disease 3.75 (2.23–6.29, < 0.01) 2.00 (1.47–2.72, < 0.01) 1.36 (1.12–1.64, 0.01)
Chronic kidney disease
Surgical admission 1.79 (1.44–2.23, < 0.01) 1.39 (1.14–1.71, < 0.01) 1.23 (1.05–1.72, < 0.01)
Vasopressor use 1.48 (1.04–2.12, 0.03) 1.34 (1.05–1.65, 0.01) 1.41 (1.19–1.69, < 0.01)
Mechanical ventilation 1.39 (1.09–2.12, < 0.01) 1.38 (1.16–1.31, < 0.01) 1.53 (1.33–1.73, < 0.01)
Moderate anemia
APACHE III score 1.02 (1.02–1.03, < 0.01) 1.02 (1.02–1.26, < 0.01) 1.03 (1.02–1.04, < 0.01) 1.03 (1.03–1.03, < 0.01)
eGFR 0.98 (0.98–0.99, < 0.01) 0.98 (0.98–0.99, < 0.01)
Hypotensive Index 1.13 (1.04–1.24, < 0.01) 1.04 (1.01–1.07, 0.01)
ACE inhibitor/ARB
Vancomycin 1.46 (1.00–2.13, 0.04) 1.56 (1.13–1.39, < 0.01) 1.39 (1.08–1.77, 0.01) 1.45 (1.18–1.77, < 0.01)
Other antibiotics
Calcineurin inhibitor 2.72 (1.45–5.12, < 0.01) 2.45 (1.59–3.75, < 0.01)
NSAID 0.51 (0.32–0.82, < 0.01) 0.68 (0.49–0.80, 0.02) 0.78 (0.63–0.96, 0.01) 0.92 (0.80–1.07, 0.03)
Other nephrotoxic medications 1.60 (1.03–2.49, 0.03)  
AUC (Q1–Q3) 0.754 (0.732–0.776) 0.769 (0.749–0.789) 0.772 (0.757–0.787) 0.770 (0.758–0.781)
  1. OR odds ratio, CI confidence interval, APACHE Acute Physiology and Chronic Healthy Evaluation, eGFR estimated glomerular filtration rate, ACE angiotensin-converting enzyme, ARB angiotensin II receptor blocker, NSAID nonsteroidal anti-inflammatory drug, ROC receiver operator curve