The effect of multidisciplinary extracorporeal membrane oxygenation team on clinical outcomes in patients with severe acute respiratory failure

Annals of Intensive Care

Table 2 Medical management prior to extracorporeal membrane oxygenation

	Pre-ECMO team period (n = 70)	Post-ECMO team period (n = 46)	P value
Duration of MV before ECMO, days	2 (0–6)	2 (0–7)	0.510
Pre-ECMO ventilator settings^a
PaO₂/FiO₂	71.5 (56.0–96.5)	91.8 (68.3–114.3)	0.033
FiO2 (%)	100 (100–100)	100 (70–100)	0.009
PEEP (cmH₂O)	10 (5–12)	10 (5–12)	0.239
Peak inspiratory pressure (cmH₂O)	30 (24–34)	28 (23–31)	0.402
Minute volume (L)	9.1 (6.8–11.2)	9.5 (8.2–11.9)	0.420
VT/PBW (mL/kg)	6.8 (5.1–8.0)	6.8 (5.9–8.6)	0.710
Pre-ECMO treatment
Steroid	46 (65.7)	19 (41.3)	0.010
Neuromuscular blocking agent	35 (50.0)	26 (56.5)	0.491
Inhaled nitric oxide	8 (11.4)	12 (26.1)	0.041
Prone position	4 (5.7)	10 (21.7)	0.010
Vasopressor infusion	44 (62.9)	29 (63.0)	0.984
Pre-ECMO blood gas
pH	7.26 (7.13–7.38)	7.22 (7.09–7.35)	0.333
PaCO₂ (mmHg)	58.1 (45.8–73.5)	57.8 (44.7–68.5)	0.699
PaO₂ (mmHg)	61.4 (55.0–74.2)	64.2 (54.8–84.5)	0.726
HCO₃ (mmol/L)	25.8 (21.8–30.2)	23.2 (19.2–28.2)	0.063
SaO₂ (%)	89.4 (85.6–92.1)	89.4 (82.6–94.5)	0.890
Lactate before ECMO (mmol/L)	2.26 (1.53–4.80)	2.10 (1.60–5.11)	0.948

Values are given as the median (interquartile range) or n (%)
ECMO extracorporeal membrane oxygenation, FiO₂ fraction of inspired oxygen, MV mechanical ventilation, PaCO₂ partial pressure of carbon dioxide in arterial blood, PaO₂ partial pressure of oxygen in arterial blood, PBW predicted body weight, PEEP positive end-expiratory pressure, SaO₂ arterial oxygen saturations, VT tidal volume
^aData were available for 104 patients (66 patients in the pre-ECMO team period and 40 patients in the post-ECMO team period)