Table 2 Patient outcomes
From: Predictors of response to fixed-dose vasopressin in adult patients with septic shock
Outcome | Total (N = 938) | Non-responders (N = 512) | Responders (N = 426) | P value |
|---|---|---|---|---|
In-hospital mortality, n (%) | 608 (64.8) | 367 (71.7) | 241 (56.6) | < 0.001 |
ICU mortality, n (%) | 561 (59.8) | 347 (67.8) | 214 (50.2) | < 0.001 |
ICU-free days at day 14 | 1.9 ± 3.6 | 1.6 ± 3.3 | 2.3 ± 3.8 | < 0.001 |
Hospital-free days at day 28 | 3.4 ± 6.6 | 2.8 ± 6.0 | 4.2 ± 7.2 | < 0.001 |
MV-free days at day 14 | 2.8 ± 4.9 | 2.2 ± 4.5 | 3.6 ± 5.3 | < 0.001 |
SOFA score changea | 0.6 ± 2.9 | 0.8 ± 2.9 | 0.3 ± 2.9 | 0.02 |
Respiration score change | 2.3 ± 1.5 | 2.0 ± 1.5 | 2.5 ± 1.4 | < 0.001 |
Coagulation score change | 0.46 ± 1.0 | 0.5 ± 0.9 | 0.4 ± 1.0 | 0.19 |
Liver score change | 0.1 ± 0.7 | 0.1 ± 0.8 | 0.7 ± 0.6 | 0.90 |
Neurological score change | − 0.1 ± 1.1 | 0.1 ± 1.1 | − 0.2 ± 1.0 | < 0.001 |
Cardiovascular score change | − 1.9 ± 1.7 | − 1.6 ± 1.7 | − 2.1 ± 1.7 | < 0.001 |
CRRT initiation between AVP start and 72 h, n (%)b | 190 (25.0) | 112 (30.0) | 78 (20.2) | 0.002 |
CA dose changec, mcg/min | +1.7 ± 40.6 | +13.8 ± 51.2 | − 12.8 ± 9.6 | < 0.001 |
CA-free days at day 14 | 5.0 ± 5.8 | 3.9 ± 5.5 | 6.3 ± 6.0 | < 0.001 |