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Table 2 Patient outcomes

From: Predictors of response to fixed-dose vasopressin in adult patients with septic shock

Outcome Total (N = 938) Non-responders (N = 512) Responders (N = 426) P value
In-hospital mortality, n (%) 608 (64.8) 367 (71.7) 241 (56.6) < 0.001
ICU mortality, n (%) 561 (59.8) 347 (67.8) 214 (50.2) < 0.001
ICU-free days at day 14 1.9 ± 3.6 1.6 ± 3.3 2.3 ± 3.8 < 0.001
Hospital-free days at day 28 3.4 ± 6.6 2.8 ± 6.0 4.2 ± 7.2 < 0.001
MV-free days at day 14 2.8 ± 4.9 2.2 ± 4.5 3.6 ± 5.3 < 0.001
SOFA score changea 0.6 ± 2.9 0.8 ± 2.9 0.3 ± 2.9 0.02
 Respiration score change 2.3 ± 1.5 2.0 ± 1.5 2.5 ± 1.4 < 0.001
 Coagulation score change 0.46 ± 1.0 0.5 ± 0.9 0.4 ± 1.0 0.19
 Liver score change 0.1 ± 0.7 0.1 ± 0.8 0.7 ± 0.6 0.90
 Neurological score change − 0.1 ± 1.1 0.1 ± 1.1 − 0.2 ± 1.0 < 0.001
 Cardiovascular score change − 1.9 ± 1.7 − 1.6 ± 1.7 − 2.1 ± 1.7 < 0.001
CRRT initiation between AVP start and 72 h, n (%)b 190 (25.0) 112 (30.0) 78 (20.2) 0.002
CA dose changec, mcg/min +1.7 ± 40.6 +13.8 ± 51.2 − 12.8 ± 9.6 < 0.001
CA-free days at day 14 5.0 ± 5.8 3.9 ± 5.5 6.3 ± 6.0 < 0.001
  1. CA catecholamine, CRRT continuous renal replacement therapy, MV mechanical ventilation, SOFA sequential organ failure assessment
  2. aEvaluated at hour 48 after vasopressin initiation
  3. bEvaluated only in patients who survived at least 24 h after vasopressin initiation
  4. cEvaluated at hour 6 after vasopressin initiation
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