Predictors of response to fixed-dose vasopressin in adult patients with septic shock

Table 3 Results of multivariable analyses

Outcome	OR (95% CI)	P value
Multivariable analysis and association with response to vasopressin^a
Non-medical ICU	1.70 (1.18–2.46)	0.005
Lactate at AVP initiation, mmol/L	0.93 (0.89–0.97)	< 0.001
Multivariable analysis and association with ICU mortality
Hemodynamic response to AVP	0.51 (0.35–0.76)	0.001
Catecholamine dose, mcg/kg/min	3.14 (1.36–7.28)	0.008
Lactate at AVP initiation, mmol/L	1.10 (1.04–1.18)	0.002
AKI presence
Rifle versus no AKI	3.64 (1.77–7.49)	< 0.001
Injury versus no AKI	5.80 (1.13–29.60)	0.035
Failure versus no AKI	2.63 (1.38–5.01)	0.003
ESRD versus no AKI	2.37 (1.27–4.43)	0.007
APACHE III score	1.01 (1.01–1.02)	< 0.001
SOFA score	1.16 (1.08–1.25)	< 0.001
Medical ICU	1.58 (1.02–2.45)	0.040
Race (Caucasian)	1.72 (1.14–2.60)	0.010
Age	1.01 (1.00–1.03)	0.036
Hepatic failure	0.89 (0.48–1.62)	0.696

AKI acute kidney injury, AVP vasopressin, ESRD end-stage renal dysfunction, SOFA sequential organ failure assessment
^aVariables entered into the model but without a statistically significant association with vasopressin response include RIFLE-defined AKI category, corticosteroid use, SOFA score, APACHE III score, hepatic failure, race, age, and catecholamine dosage (in mcg/kg/min)