From: Predictors of response to fixed-dose vasopressin in adult patients with septic shock
Cohort of interest | Responders N (%) | Non-responders N (%) | P value | OR (95% CI) hemodynamic response | OR (95% CI) ICU mortality |
---|---|---|---|---|---|
Corticosteroids | |||||
Yes | 251 (58.9) | 320 (62.5) | 0.26 | 0.86 (0.66–1.12) | 1.01 (0.77–1.32) |
Noa | 175 (41.1) | 192 (37.5) | |||
Lactate concentration | |||||
> 1.4 mmol/La | 211 (78.4) | 321 (88.7) | < 0.001 | 2.15 (1.39–3.32)^ | 0.39 (0.25–0.60)^ |
≤ 1.4 mmol/L | 58 (21.6) | 41 (11.3) | |||
BMI classification | |||||
Underweighta | 18 (4.2) | 20 (3.9) | 0.98 | ||
Normal | 94 (22.1) | 106 (20.7) | 0.99 (0.50–1.97) | 1.09 (0.53–2.12) | |
Overweight | 114 (26.8) | 140 (27.3) | 0.90 (0.46–1.79) | 1.02 (0.51–2.05) | |
Obesity class I | 81 (19.0) | 101 (19.7) | 0.89 (0.44–1.80) | 0.91 (0.45–1.86) | |
Obesity class II | 48 (11.3) | 53 (10.4) | 1.01 (0.48–2.12) | 1.13 (0.52–2.43) | |
Obesity class III | 71 (16.7) | 92 (18.0) | 0.86 (0.42–1.74) | 0.77 (0.37–1.57) | |
CA equivalent dose | |||||
≥ 15 mcg/mina | 370 (86.9) | 424 (82.8) | 0.087 | 0.57 (0.36–0.92)^ | 0.62 (0.44–0.89)^ |
< 15 mcg/min | 56 (13.1) | 88 (17.2) | |||
Total vasopressor quantity | |||||
1 Vasopressora | 370 (86.9) | 463 (90.4) | 0.084 | 1.43 (0.95–2.15) | 1.98 (1.26–3.12)^ |
> 1 Vasopressor | 56 (13.1) | 49 (9.6) | |||
Renal insufficiency | |||||
Yes | 220 (51.6) | 268 (52.3) | 0.83 | 0.97 (0.75–1.26) | 1.59 (1.23–2.07)^ |
Noa | 206 (48.4) | 244 (47.7) | |||
AKI class | |||||
No AKI presencea | 258 (60.6) | 308 (60.2) | 0.21 | ||
AKI-risk | 29 (6.8) | 50 (9.8) | 0.69 (0.43–1.13) | 2.40 (1.43–4.03)^ | |
AKI-injury | 11 (2.6) | 21 (4.1) | 0.63 (0.30–1.32) | 3.30 (1.41–7.76)^ | |
AKI-failure | 67 (15.7) | 75 (14.6) | 1.07 (0.74–1.54) | 3.06 (2.00–4.66)^ | |
AKI-end stage | 61 (14.3) | 58 (11.3) | 1.26 (0.85–1.87) | 1.64 (1.09–2.46)^ |