Fig. 2

mHLA-DR measurements in pediatric septic shock. a mHLA-DR expression in healthy children: no difference according to age groups (p = 0.35; ANOVA). Dashed line depicts usual threshold to define normal values in adults. b mHLA-DR was significantly decreased at each time point during septic shock, than controls (p < 0.001; Mann–Whitney). c mHLA-DR at day 3–5 was significantly negatively correlated with cumulative vasopressor index, CVI (r = − 0.50; p = 0.031; Spearman). d mHLA-DR was significantly lower in children with secondary acquired infection than those without (p = 0.022; Student t test)