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Annals of Intensive Care

Table 4 Performance of qSOFA and SIRS in predicting sepsis and mortality

From: Mortality and detailed characteristics of pre-ICU qSOFA-negative patients with suspected sepsis: an observational study

 

Sepsis by Sepsis-3 definition

In-hospital mortality

n/N (%)

Crude risk ratio (95% CI)

AUROC

n/N (%)

Crude risk ratio (95% CI)

AUROC

Pre-ICU qSOFA

  

0.711

  

0.511

 qSOFA-positive (≥ 2)

149/159 (93.7%)

1.16 (0.96–1.41)

 

48/159 (30.2%)

1.38 (0.62–2.74)

 

 qSOFA-negative (< 2)

21/26 (80.8%)

1.00 (ref)

 

6/26 (23.1%)

1.00 (ref)

 

Pre-ICU SIRS

  

0.710

  

0.521

 SIRS-positive (≥ 2)

155/166 (93.4%)

1.18 (0.93–1.50)

 

48/166 (28.9%)

0.92 (0.45–1.85)

 

 SIRS-negative (< 2)

15/19 (78.9%)

1.00 (ref)

 

6/19 (31.6%)

1.00 (ref)

 

qSOFA at ICU arrival

  

0.624

  

0.586

 qSOFA-positive (≥ 2)

92/98 (93.9%)

1.05 (0.96–1.14)

 

36/98 (36.7%)

1.78 (1.09–2.89)

 

 qSOFA-negative (< 2)

78/87 (89.7%)

1.00 (ref)

 

18/87 (20.7%)

1.00 (ref)

 

SIRS at ICU arrival

  

0.709

  

0.541

 SIRS-positive (≥ 2)

133/139 (95.7%)

1.19 (1.03–1.38)

 

41/139 (29.5%)

1.04 (0.62–1.77)

 

 SIRS-negative (< 2)

37/46 (80.4%)

1.00 (ref)

 

13/46 (28.3%)

1.00 (ref)

 
  1. Pre-ICU qSOFA and SIRS scores were assessed with the most abnormal vital signs taken during the 24-h period before the ICU admission. qSOFA and SIRS scores at ICU arrival were assessed with the first measurements just after ICU admission
  2. Sepsis was defined according to the Sepsis-3 definition. In-hospital mortality was defined as any cause of death censored at 90 days after the ICU admission
  3. AUROC area under receiver operating characteristics, CI confidence interval, ICU intensive care unit, qSOFA quick Sequential Organ Failure Assessment, SIRS systemic inflammatory response syndrome
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