Metabolic disturbances on admission | Propensity score-matched controls (n = 178) | Cirrhosis (n = 178) | p value for overall cirrhosis versus matched controls | p value for the effect of ACLF category* | |||
---|---|---|---|---|---|---|---|
Overall cirrhosis (n = 178) | ACLF category | ||||||
No ACLF (n = 21) | ACLF grade 1 and 2 (n = 72) | ACLF grade III (n = 85) | |||||
Acidemia | 87 (49%) | 86 (48%) | 4 (19%) | 29 (40%) | 53 (62%) | 1.00 | < 0.01 |
Alkalemia | 35 (20%) | 52 (29%) | 11 (52%) | 21 (29%) | 20 (24%) | < 0.05 | < 0.05 |
Respiratory acidosis | 64 (36%) | 41 (23%) | 3 (14%) | 13 (18%) | 25 (29%) | < 0.05 | 0.052 |
Respiratory alkalosis | 55 (31%) | 88 (49%) | 10 (48%) | 40 (56%) | 38 (45%) | < 0.01 | 0.338 |
Metabolic acidosis | 89 (50%) | 112 (63%) | 7 (33%) | 45 (63%) | 60 (71%) | < 0.05 | < 0.01 |
Metabolic alkalosis | 38 (21%) | 33 (19%) | 4 (19%) | 16 (22%) | 13 (15%) | 0.596 | 0.365 |
Dilutional acidosis | 1 (0.6%) | 11 (6%) | 0 | 4 (6%) | 7 (8%) | < 0.01 | 0.205 |
Concentrational alkalosis | 2 (1.1%) | 6 (3%) | 0 | 6 (8%) | 0 | 0.289 | 0.136 |
Hyperchloremic acidosis | 98 (55%) | 78 (44%) | 11 (52%) | 32 (44%) | 35 (41%) | < 0.05 | 0.399 |
Hypochloremic alkalosis | 7 (4%) | 15 (8%) | 0 | 8 (11%) | 7 (8%) | 0.134 | 0.702 |
Hypoalbuminemic alkalosis | 58 (33%) | 86 (48%) | 11 (52%) | 36 (50%) | 39 (46%) | < 0.01 | 0.516 |
Acidosis owing to unmeasured anions | 32 (18%) | 48 (27%) | 1 (5%) | 16 (22%) | 31 (37%) | 0.061 | < 0.01 |
Lactic acidosis | 65 (37%) | 118 (66%) | 7 (33%) | 44 (61%) | 67 (79%) | < 0.01 | < 0.01 |