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Table 4 Cox regression model for risk factors for mortality in critically ill patients with liver cirrhosis

From: Acid–base status and its clinical implications in critically ill patients with cirrhosis, acute-on-chronic liver failure and without liver disease

Parameter Hazard ratio (95% CI)
Univariate Multivariate
Age 1.02 (1.00–1.04)* 1.02 (1.00–1.04)*
Sex (male gender) 0.75 (0.51–1.11) 0.77 (0.51–1.15)
Liver disease
 ACLF grade 1 versus no ACLF 1.80 (0.63–5.19) 1.36 (0.47–4.01)
 ACLF grade 2 versus no ACLF 2.02 (0.76–5.37) 1.44 (0.53–3.94)
 ACLF grade 3 versus no ACLF 5.52 (2.22–13.74)** 3.68 (1.42–9.52)**
 Sepsis/infection 1.69 (1.09–2.61)* 1.21 (0.76–1.92)
Base excess
 BENa 0.96 (0.90–1.03) 0.96 (0.89–1.04)
 BECl 1.00 (0.98–1.03) 0.97 (0.93–1.00)
 BEAlb 0.91 (0.81–1.02) 0.89 (0.79–1.00)
 BEUMA 0.95 (0.93–0.97)** 0.96 (0.92–0.99)*
 BElactate 0.88 (0.85–0.92)** 0.92 (0.88–0.97)**
  1. ACLF acute-on-chronic liver failure, BE Na BE caused by free water effect, BE Cl BE caused by changes in chloride, BE Alb BE caused by albumin effect, BE lactate BE attributable to lactate elevation, BE UMA BE attributable to unmeasured anions
  2. *p value < 0.05; **p value < 0.01