Table 1 Haemodynamic values for each group at baseline and after fluid resuscitation and norepinephrine infusion
T0 | T1 | T2 | T3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Control | MID1 | MID2 | Control | MID1 | MID2 | Control | MID1 | MID2 | Control | MID1 | MID2 | |
HR (/min) | 220 [213–221] | 221 [219–229] | 222 [219–226] | 192 [190–192]△ | 201 [191–204]△ | 191 [190–194]△ | 188 [185–191]△ | 219 [215–228]*& | 218 [211–224]*& | 193 [191–195]△ | 202 [189–203]△^ | 192 [191–194]△^ |
SBP (mmHg) | 131 [130–134] | 130 [129–130] | 130 [126–135] | 142 [136–150]△ | 148 [141–151]△ | 146 [141–152]△ | 143 [137–150]△ | 129 [126–133]*& | 108 [107–108]*#△& | 135 [131–141] | 137 [135–138]& | 142 [135–147]△^ |
DBP (mmHg) | 78 [76–80] | 79 [75–80] | 77 [75–80] | 84 [81–85] | 86 [82–88] | 88 [82–89] | 80 [79–84] | 71 [70–77]& | 57 [56–60]*#△& | 79 [78–82] | 80 [76–80]^ | 77 [76–78]&^ |
MAP (mmHg) | 96 [92–98] | 94 [93–96] | 96 [92–97] | 105 [98–108]△ | 104 [101–108]△ | 106 [104–110]△ | 103 [95–107]△ | 90 [87–95]*& | 74 [72–76]*#△& | 99 [96–103] | 98 [97–99]&^ | 97 [96–99]&^ |
CVP (mmHg) | 0 [0–1] | 1 [0–1] | 0 [0–0] | 4 [3, 4]△ | 4 [3–5]△ | 2 [2–4]△ | 4 [3–4]△ | 3 [3–3]△& | 1 [1–2]*#△& | 4 [3–4]△ | 5 [4–5]△^ | 3 [2–4]△^ |
CO (L/min) | 0.70 [0.68–0.70] | 0.71 [0.69–0.72] | 0.79 [0.77–0.81] | 0.97 [0.95–0.98]△ | 0.90 [0.89–0.96]△ | 0.96 [0.95–1.01]△ | 0.97 [0.95–1.00]△ | 0.83 [0.82–0.88]*△& | 0.74 [0.71–0.76]*& | 0.97 [0.95–0.98]△ | 0.90 [0.89–0.96]△^ | 0.96 [0.95–1.01]△^ |
SV (mL) | 3.16 [2.97–3.42] | 3.19 [3.13–3.40] | 3.53 [3.46–3.64] | 5.04 [4.97–5.09]△ | 4.77 [4.48–4.84]△ | 4.96 [4.82–5.28]△ | 5.04 [4.91–5.13]△ | 3.96 [3.76–4.07]*△& | 3.42 [3.18–3.67]*& | 4.99 [4.93–5.06]△ | 4.72 [4.46–4.94]△^ | 4.96 [4.81–5.25]△^ |
GEDV (mL) | 51.73 [50.96,51.95] | 52.61 [52.42,53.10] | 52.29 [51.96,52.93] | 85.10 [79.61,91.04]△ | 83.68 [80.95,86.80]△ | 84.04 [77.73,85.20]△ | 85.60 [79.14,90.79]△ | 79.88 [74.58,81.53]△& | 61.15 [58.22,63.21]*#△& | 85.15 [79.36,90.35]△ | 87.28 [81.01,87.96]△^ | 84.84 [77.70,87.06]△^ |
PPV (%) | 19 [17–21] | 17 [16–21] | 18 [17–19] | 12 [9–14]△ | 9 [7–10]△ | 9 [8–10]△ | 12 [10–14]△ | 14 [12–14]△& | 18 [17–20]*#& | 12 [10–14]△ | 10 [10–11]△ | 11 [9–12]△^ |
SVV (%) | 20 [18–22] | 19 [17–21] | 17 [16–21] | 12 [11–13]△ | 9 [7–10]△ | 10 [8–10]△ | 11 [10–12]△ | 15 [14–16]*△& | 19 [18–20]*#& | 11 [10–12]△ | 10 [9–11]△^ | 10 [8–10]△^ |
Pmsf (mmHg) | 11.38 [10.66–11.74] | 11.25 [9.82–12.18] | 10.21 [9.84–10.83] | 15.10 [14.37–15.33]△ | 15.25 [12.80–15.90]△ | 13.66 [13.32–14.44]△ | 13.96 [12.62–15.19]△ | 11.99 [11.39–12.33]*& | 7.47 [7.12–8.18]*#△& | 15.04 [14.43–15.21]△ | 14.67 [13.05–16.48]△^ | 13.84 [11.78–14.05]△^ |
Rsys (mmHg min kg/L) | 433.07 [407.43–467.57] | 425.39 [415.13–447.27] | 391.68 [385.29–396.17] | 313.44 [285.22–349.96]△ | 344.17 [335.74–378.40]△ | 345.42 [329.23–359.34]△ | 307.07 [275.76–354.48]△ | 325.91 [319.91–364.31]△ | 321.84 [315.46–330.69]△ | 304.85 [277.58–330.59]△ | 330.35 [329.47–345.24]△ | 311.64 [295.34–331.80]△ |
Ra (mmHg min kg/L) | 381.99 [359.36–415.32] | 376.87 [371.82–395.45] | 351.96 [348.17–354.64] | 281.67 [246.52–309.64]△ | 309.23 [297.37–339.03]△ | 315.84 [291.55–322.58]△ | 277.14 [238.35–317.62]△ | 294.21 [284.26–328.25]△ | 295.30 [286.45–306.61]△ | 268.01 [240.22–293.72]△ | 294.57 [288.36–300.60]△ | 279.84 [267.47–298.88]△ |
Rvr (mmHg min kg/L) | 50.00 [47.22–52.25] | 47.09 [44.35–51.98] | 42.41 [38.80–44.46] | 37.02 [30.15–39.24]△ | 39.42 [35.58–39.94]△ | 37.12 [32.12–39.78] | 36.71 [26.93–37.80]△ | 36.04 [33.01–36.69]△ | 28.05 [26.93–29.48]#△& | 36.80 [29.28–41.45]△ | 36.90 [29.71–41.42]△ | 32.08 [30.10–33.84]△ |
CFI (/min) | 13.41 [13.25–13.51] | 13.52 [13.22–13.55] | 14.89 [14.35–15.52] | 11.82 [11.33–12.46]△ | 10.97 [10.62–11.19]△ | 12.23 [11.54–12.30]△ | 11.86 [11.29–12.49]△ | 10.81 [10.25–11.29]△ | 12.26 [11.34–12.46]△ | 11.86 [11.29–12.49]△ | 10.81 [10.25–11.29]△ | 12.26 [11.34–12.46]△ |