Midazolam increases preload dependency during endotoxic shock in rabbits by affecting venous vascular tone

Annals of Intensive Care

Table 2 Fluid and norepinephrine administration during the experiment

Treatment	T0–T1			T1–T2			T2–T3
Treatment	Control	MID1	MID2	Control	MID1	MID2	Control	MID1	MID2
Saline (mL)	343.33 ± 16.32	350.00 ± 12.64	345.00 ± 13.78	29.10 ± 1.46	29.70 ± 1.13	29.25 ± 1.24	29.10 ± 1.46	45.40 ± 1.19*	65.21 ± 1.16*#
Norepinephrine (mcg kg⁻¹ min⁻¹)	5.51 ± 0.23	5.55 ± 0.21	5.56 ± 0.27	5.51 ± 0.23	5.55 ± 0.21	5.56 ± 0.27	5.51 ± 0.23	5.55 ± 0.21	5.56 ± 0.27

Data are shown as the mean ± SD
T0: baseline; T1: endotoxic shock after fluid resuscitation and norepinephrine infusion; T2: after the administration of midazolam at 0.3 mg kg⁻¹ h⁻¹ (MID1) or 3 mg kg⁻¹ h⁻¹ (MID2); T3: after second round of fluid resuscitation
*p < 0.05 versus control, #p < 0.05 versus MID1