Annals of Intensive Care

Table 3 Analysis of blood gas with increasing midazolam infusion rates

From: Midazolam increases preload dependency during endotoxic shock in rabbits by affecting venous vascular tone

	T0			T1			T2			T3
	Control	MID1	MID2	Control	MID1	MID2	Control	MID1	MID2	Control	MID1	MID2
pHa	7.30 ± 0.09	7.34 ± 0.03	7.27 ± 0.07	7.23 ± 0.05	7.24 ± 0.03	7.38 ± 0.06	7.23 ± 0.08	7.22 ± 0.05	7.24 ± 0.07	7.25 ± 0.06	7.24 ± 0.03	7.32 ± 0.06
PCO₂ (mmHg)	33.78 ± 9.57	33.93 ± 5.07	33.70 ± 6.14	35.63 ± 7.46	33.91 ± 4.92	34.12 ± 5.68	33.71 ± 6.14	34.10 ± 5.07	36.71 ± 6.02	33.81 ± 5.98	33.98 ± 5.12	35.12 ± 5.82
P/F (mmHg)	339.65 ± 71.59	308.55 ± 35.01	348.02 ± 64.01	299.75 ± 69.52	296.15 ± 59.58	297.68 ± 67.35	292.51 ± 50.51	298.30 ± 21.10	290.51 ± 38.62	296.62 ± 48.91	298.50 ± 22.30	298.36 ± 35.72
Lac (mmol/L)	2.90 ± 0.69	2.90 ± 0.54	2.45 ± 0.97	2.91 ± 1.31	2.93 ± 1.35	3.12 ± 1.02	2.2 ± 0.98	2.3 ± 0.85	2.91 ± 1.01	2.1 ± 0.87	2.2 ± 0.75	2.6 ± 0.98
Hb (g/dL)	8.5 ± 0.5	8.5 ± 0.6	8.5 ± 0.6	8.3 ± 0.5	8.6 ± 0.7	8.3 ± 0.8	8.3 ± 0.5	8.4 ± 0.3	8.5 ± 0.4	8.6 ± 0.4	8.2 ± 0.5	8.5 ± 0.4
HCO₃⁻ (mmol/L)	16.2 ± 2.4	16.1 ± 1.6	16.7 ± 3.3	15.79 ± 1.9	16.25 ± 2.3	16.35 ± 1.8	16.68 ± 3.42	16.31 ± 2.31	16.31 ± 2.52	17.08 ± 3.06	16.52 ± 2.11	17.31 ± 1.98
SvO₂ (%)	88.13 ± 2.93	88.18 ± 2.98	85.68 ± 4.27	85.46 ± 3.96	85.17 ± 3.12	86.35 ± 3.03	85.67 ± 4.12	85.28 ± 3.12	85.69 ± 3.06	86.28 ± 4.35	86.28 ± 4.84	85.39 ± 2.98

Data are shown as the mean ± SD
T0: baseline; T1: endotoxic shock after the fluid resuscitation and norepinephrine infusion; T2: after the administration of midazolam at 0.3 mg kg⁻¹ h⁻¹ (MID1) or 3 mg kg⁻¹ h⁻¹ (MID2); T3: after the second round of fluid resuscitation
pHa, pH of artery; PCO₂, partial pressure of carbon dioxide; P/F, alveolar oxygen partial pressure/fraction of inspiration O₂; Lac, lactic acid; Hb, haemoglobin; HCO₃⁻, bicarbonate; SvO₂, oxygen saturation of mixed venous blood; SD, standard deviation
There was no significant difference between Control, MID1 and MID2 groups at T0, T1, T2 or T3, respectively

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