Hypothermic total liquid ventilation after experimental aspiration-associated acute respiratory distress syndrome

Annals of Intensive Care

Table 2 Biochemical characteristics throughout protocol in rabbits presenting experimental acute respiratory distress syndrome and treated by gaseous lung protective ventilation (LPV) or total liquid ventilation (TLV), respectively

Parameters and groups	Baseline	Conventional ventilation (t = 90 min)	LPV or TLV
Parameters and groups	Baseline	Conventional ventilation (t = 90 min)	30 min	120 min
Arterial blood saturation (%)
LPV	100 ± 0	76 ± 4	62 ± 9	80 ± 5
TLV	100 ± 0	73 ± 3	83 ± 12	90 ± 2
Arterial blood pH
LPV	7.36 ± 0.03	7.15 ± 0.06	7.14 ± 0.15	7.18 ± 0.05
TLV	7.35 ± 0.04	7.22 ± 0.02	7.17 ± 0.04	7.16 ± 0.04
Arterial blood PaO₂ (mmHg)
LPV	227 ± 29	41 ± 5	62 ± 9	52 ± 8
TLV	219 ± 38	51 ± 9	83 ± 12	62 ± 4
Arterial blood PaO₂/FiO₂ (mmHg)
LPV	755 ± 97	41 ± 5	62 ± 9	52 ± 8
TLV	730 ± 150	51 ± 9	83 ± 12	62 ± 4
Arterial blood PaCO₂ (mmHg)
LPV	47 ± 3	70 ± 11	68 ± 7	67 ± 7
TLV	49 ± 6	72 ± 4	80 ± 5	79 ± 4
Bicarbonate blood level (mmol/l)
LPV	28 ± 2	24 ± 2	23 ± 1	24 ± 2
TLV	28 ± 1	29 ± 2	30 ± 1*	31 ± 2*

Statistical comparisons were only made for group effect but not among time points
n = 8 in each LPV and TLV group; Fi02, inhaled fraction of oxygen
*p < 0.05 versus LPV