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Annals of Intensive Care

Table 1 Baseline characteristics and comparison between ICU survivors versus non-survivors

From: MicroDAIMON study: Microcirculatory DAIly MONitoring in critically ill patients: a prospective observational study

Patients characteristics

n

All (97)

ICU survivors (76)

ICU non-survivors (21)

p

Male gender (n, %)

97

64 (66)

50 (65.8)

14 (66.7)

1

Age (years, n)

97

67 [46–75]

64 [44–73]

71 [56–81]

0.034

APACHE II (pts)

97

16 ± 7

14 ± 7

22 ± 6

< 0.001

SOFA (pts)

97

7 [4–10]

6 [4–9]

12 [8–15]

< 0.001

ICU admission diagnosis, n (%)

97

   

0.046

  

Trauma 37 (38.1)

34

3(8.1)

 
  

Neurologic 21 (21.6)

17

4(19)

 
  

Respiratory 11 (11.3)

8

3(27.3)

 
  

Sepsis 9 (9.3)

6

3 (33.3)

 
  

Other 19 (19.7)

11

8(42.1)

 

Heart rate (bpm)

97

79 [61–102]

77 [61–95]

96 [69–107]

0.045

Mean arterial pressure (mmHg)

97

84 ± 19

86 ± 17

79 ± 27

0.255

Vasoactive drugs (treated)

54

 

38(50)

16(76.2)

0.046

 Noradrenaline (mcg/kg/min)

52

0.28 [0.14–0.61]

   

 Dopamine (mcg/kg/min)

5

6.1 [4.8–7.4]

   

 Dobutamine (mcg/kg/min)

8

2.54 [2–4.5]

   

Cumulative Vasopressor Index

54

4 [4]

1 [0–4]

4 [2–4]

0.008

Glasgow Coma Scale (pts)

97

10 [3–15]

10 [4–15]

4 [3–14]

0.074

Mechanical ventilation (n, %)

97

91 (93.8) 

71(93.4)

21(100)

0.581

Peep (cmH2O)

91

7 [6–9]

7 [6–9]

8 [7–10]

0.095

Haemoglobin (g/dL)

97

11 ± 1.78

11.1 ± 1.7

10.8 ± 2.2

0.58

White blood cells (n × 103/mmc)

97

12.1 [8.83–14.81]

11.3 [8.8–15.7]

12.7 [9.5–14.6]

0.518

Platelets (n × 103/mmc)

97

150 [102–199]

165 [110–201]

115 [56–173]

0.02

Creatinine (mg/dL)

97

1.0 [0.8–1.45]

1 [0.8–1.2]

1.4 [1.1–1.8]

< 0.001

Bilirubine (mg/dL)

97

0.8 [0.5–1.2]

0.75 [0.5–1.1]

0.9 [0.4–1.8]

0.264

PaO2 (mmHg)

97

146 [104–175]

147 [106–176]

140 [93–172]

0.63

Arterial lactates (mmol/L)

97

1.4 [1.0–2.15]

1.3 [0.9–1.67]

3.1 [1.4–5.6]

< 0.001

 ScvO2 (%)

60

77.2 [71–82.3]

77.7 [72.3–82.5]

75.6 [62.7–80.8]

0.24

Microcirculatory variables

     

 TVD (small) (mm/mm2)

97

20.4 ± 3.7

20.5 [17.2–22.7]

20.9 [17.8–22.7]

0.817

 PVD (small) (mm/mm2)

97

19.3 ± 4.4

19.3 ± 4

19.3 ± 6

0.951

 De Backer score (small) (n/mm)

97

11.9 ± 2

11.8 ± 2

12.2 ± 2

0.489

 PPV (small) (%)

97

98.3 [95.4–100]

98.2 [94.8–100]

98.3 [97–100]

0.688

 MFI (small) (AU)

97

3 [2.7–3.0]

3 [2.75–3]

2.93 [2.3–3]

0.155

 HI (small)

97

0 [0.0–0.2]

0 [0–0.2]

0 [0–0.3]

0.417

 Abnormal MFI (n, %)

97

20 (20.6)

11 (14.5)

9 (42.9)

0.012

  1. Data are presented as mean ± or as median [IQR] unless stated otherwise
  2. APACHE acute physiologic and chronic health evaluation II, calculated over the first 24 h from ICU admission; SOFA sequential organ failure assessment, calculated over the first 24 h from ICU admission; CVI cumulative vasopressor index; ICU Intensive Care Unit; COPD, chronic obstructive pulmonary disease. TVD total vessel density; PVD perfused vessel density; PPV proportion of perfused vessel; HI Heterogeneity Index; MFI Microvascular Flow Index. Abnormal MFI is defined as MFI < 2.6. Cut-off value for small vessels diameter < 20 μm
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