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Table 1 Baseline characteristics and comparison between ICU survivors versus non-survivors

From: MicroDAIMON study: Microcirculatory DAIly MONitoring in critically ill patients: a prospective observational study

Patients characteristics n All (97) ICU survivors (76) ICU non-survivors (21) p
Male gender (n, %) 97 64 (66) 50 (65.8) 14 (66.7) 1
Age (years, n) 97 67 [46–75] 64 [44–73] 71 [56–81] 0.034
APACHE II (pts) 97 16 ± 7 14 ± 7 22 ± 6 < 0.001
SOFA (pts) 97 7 [4–10] 6 [4–9] 12 [8–15] < 0.001
ICU admission diagnosis, n (%) 97     0.046
   Trauma 37 (38.1) 34 3(8.1)  
   Neurologic 21 (21.6) 17 4(19)  
   Respiratory 11 (11.3) 8 3(27.3)  
   Sepsis 9 (9.3) 6 3 (33.3)  
   Other 19 (19.7) 11 8(42.1)  
Heart rate (bpm) 97 79 [61–102] 77 [61–95] 96 [69–107] 0.045
Mean arterial pressure (mmHg) 97 84 ± 19 86 ± 17 79 ± 27 0.255
Vasoactive drugs (treated) 54   38(50) 16(76.2) 0.046
 Noradrenaline (mcg/kg/min) 52 0.28 [0.14–0.61]    
 Dopamine (mcg/kg/min) 5 6.1 [4.8–7.4]    
 Dobutamine (mcg/kg/min) 8 2.54 [2–4.5]    
Cumulative Vasopressor Index 54 4 [4] 1 [0–4] 4 [2–4] 0.008
Glasgow Coma Scale (pts) 97 10 [3–15] 10 [4–15] 4 [3–14] 0.074
Mechanical ventilation (n, %) 97 91 (93.8)  71(93.4) 21(100) 0.581
Peep (cmH2O) 91 7 [6–9] 7 [6–9] 8 [7–10] 0.095
Haemoglobin (g/dL) 97 11 ± 1.78 11.1 ± 1.7 10.8 ± 2.2 0.58
White blood cells (n × 103/mmc) 97 12.1 [8.83–14.81] 11.3 [8.8–15.7] 12.7 [9.5–14.6] 0.518
Platelets (n × 103/mmc) 97 150 [102–199] 165 [110–201] 115 [56–173] 0.02
Creatinine (mg/dL) 97 1.0 [0.8–1.45] 1 [0.8–1.2] 1.4 [1.1–1.8] < 0.001
Bilirubine (mg/dL) 97 0.8 [0.5–1.2] 0.75 [0.5–1.1] 0.9 [0.4–1.8] 0.264
PaO2 (mmHg) 97 146 [104–175] 147 [106–176] 140 [93–172] 0.63
Arterial lactates (mmol/L) 97 1.4 [1.0–2.15] 1.3 [0.9–1.67] 3.1 [1.4–5.6] < 0.001
 ScvO2 (%) 60 77.2 [71–82.3] 77.7 [72.3–82.5] 75.6 [62.7–80.8] 0.24
Microcirculatory variables      
 TVD (small) (mm/mm2) 97 20.4 ± 3.7 20.5 [17.2–22.7] 20.9 [17.8–22.7] 0.817
 PVD (small) (mm/mm2) 97 19.3 ± 4.4 19.3 ± 4 19.3 ± 6 0.951
 De Backer score (small) (n/mm) 97 11.9 ± 2 11.8 ± 2 12.2 ± 2 0.489
 PPV (small) (%) 97 98.3 [95.4–100] 98.2 [94.8–100] 98.3 [97–100] 0.688
 MFI (small) (AU) 97 3 [2.7–3.0] 3 [2.75–3] 2.93 [2.3–3] 0.155
 HI (small) 97 0 [0.0–0.2] 0 [0–0.2] 0 [0–0.3] 0.417
 Abnormal MFI (n, %) 97 20 (20.6) 11 (14.5) 9 (42.9) 0.012
  1. Data are presented as mean ± or as median [IQR] unless stated otherwise
  2. APACHE acute physiologic and chronic health evaluation II, calculated over the first 24 h from ICU admission; SOFA sequential organ failure assessment, calculated over the first 24 h from ICU admission; CVI cumulative vasopressor index; ICU Intensive Care Unit; COPD, chronic obstructive pulmonary disease. TVD total vessel density; PVD perfused vessel density; PPV proportion of perfused vessel; HI Heterogeneity Index; MFI Microvascular Flow Index. Abnormal MFI is defined as MFI < 2.6. Cut-off value for small vessels diameter < 20 μm
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