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Table 3 Demographics and clinical data of patients with procalcitonin (PCT) stopping advice treated adherently and non-adherently to the PCT protocol

From: Adherence to a procalcitonin-guided antibiotic treatment protocol in patients with severe sepsis and septic shock

  Patients adherent to PCT stopping advice (n = 8) Patients non-adherent to PCT stopping advice (n = 18) p value
Age, years (median [IQR]) 67 [59–75] 68 [59–75] 0.560
SAPS II score (median [IQR]) 35 [31–43] 44 [28–51] 0.655
Male gender (% [95% CI]) 50.0 [15.7–84.3] 77.8 [30.6–69.4] 0.197
ICU mortality (% [95% CI]) 12.5 [0.3–52.7] 33.3 [13.3–59.0] 0.375
Ventilation hours (median [IQR]) 353 [68–621] 735 [209–1508] 0.317
ICU LOS, days (median [IQR]) 24 [3–38] 23 [12–59] 0.780
Hospital LOS, days (median [IQR]) 57 [47–79] 54 [34–100] 0.824
SOFA score max (median [IQR]) 11 [9–12] 12 [9–13] 0.557
Length of antibiotic treatment, days (median [IQR]) 7 [6–9] 12 [9–16] 0.002
Antibiotic use density, DDD (median [IQR]) 10 [7–12] 18 [12–26] 0.001
Initial PCT value, ng/mL (median [IQR]) 20.0 [9.4–38.2] 16.8 [2.0–42.7] 0.560
Peak PCT value, ng/mL (median [IQR]) 32.3 [9.4–64.2] 44.9 [13.9–69.7] 0.718
  % [95% CI] (n) % [95% CI] (n)
Cause of infection
Abdominal sepsis 87.5 [47.3–99.7] (7) 44.4 [21.5–69.2] (8)
Bloodstream infection 0 0
Pleural empyema 0 16.7 [3.5–41.4] (3)
Pneumonia 12.5 [0.3–52.7] (1) 33.3 [13.3–59.0] (6)
Prosthetic infection 0 0
Urogenital sepsis 0 5.6 [0.1–27] (1)
Soft tissue infection 0 0
Unknown 0 0
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