Annals of Intensive Care

Table 1 Demographic characteristics

From: Impact of fluid challenge increase in cardiac output on the relationship between systemic and cerebral hemodynamics in severe sepsis compared to brain injury and controls

	Control n = 17	Brain injury n = 11	Sepsis^a n = 38 (63% septic shock)
Age (years)	48 (34–59)	58 (41–66)	64 (54–79)
Sexe (female)	12 (70%)	2 (18%)	16 (46%)
Charlson	1 (0–2)	2 (1–4)	3 (2–6)
Hypertension	0	6 (55%)	11 (29%)
Reason for admission	NA	Traumatic 8 (73%)	Abdominal 14 (37%)
		Hemorrhagic stroke 3 (27%)	Pulmonary 10 (27%)
			Skin 7 (18%)
			Other 7 (18%)
SAPS II at admission	NA	49 (42–66)	53 (38–64)
SOFA at inclusion	NA	7 (3–9)	6 (4–11)
Day of FL^b	NA	0.5 (0–1)	1 (0–3)
MAP (mmHg)	74 (65–89)	89 (77–96)	67 (56–75)
PaCO₂ (mmHg)	NA	38 (35–42)	39 (36–42)
ETCO₂ (mmHg)	NA	34 (30–36)	33 (27–35)
Natremia (mmol l⁻¹)	NA	138 (133–141)	141 (138–144)
Glycemia (mmol l⁻¹)	NA	6.8 (6.8–9.6)	7.3 (5.8–8.6)
Temperature (°C)	NA	37 (37.2–38.0)	37 (36.5–38)
Propofol	17 (100%)	11 (100%)	38 (100%)
Midazolam	0	7 (64%)	11 (29%)
Ketamine	0	0	8 (21%)
Fentanyl	0	9 (82%)	20 (53%)
Norepinephrine	0	7 (64%)^c	24 (63%)^d
Epinephrine	0	0	2 (5%)^e

Continuous values were expressed as median (25th–75th); discontinuous values were expressed with percentage
SAPSII Simplified Acute Physiology Score, SOFA sequential organ failure assessment, NA non available, FL fluid loading, MAP mean arterial pressure, ETCO₂ end-tidal CO₂
^aSepsis group: 14/38 (37%) severe sepsis, 24/38 (63%) septic shock
^bD0 was the day of admission in ICU
^cMean dose 2.3 (0.7–2.8) mg h⁻¹
^dMean dose 2.8 (0.7–3.5) mg h⁻¹
^eMean dose 0.25 (0.2–0.29) µg kg⁻¹ min⁻¹

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