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Table 1 Demographic characteristics

From: Impact of fluid challenge increase in cardiac output on the relationship between systemic and cerebral hemodynamics in severe sepsis compared to brain injury and controls

  Control
n = 17
Brain injury
n = 11
Sepsisa
n = 38 (63% septic shock)
Age (years) 48 (34–59) 58 (41–66) 64 (54–79)
Sexe (female) 12 (70%) 2 (18%) 16 (46%)
Charlson 1 (0–2) 2 (1–4) 3 (2–6)
Hypertension 0 6 (55%) 11 (29%)
Reason for admission NA Traumatic 8 (73%) Abdominal 14 (37%)
Hemorrhagic stroke 3 (27%) Pulmonary 10 (27%)
Skin 7 (18%)
Other 7 (18%)
SAPS II at admission NA 49 (42–66) 53 (38–64)
SOFA at inclusion NA 7 (3–9) 6 (4–11)
Day of FLb NA 0.5 (0–1) 1 (0–3)
MAP (mmHg) 74 (65–89) 89 (77–96) 67 (56–75)
PaCO2 (mmHg) NA 38 (35–42) 39 (36–42)
ETCO2 (mmHg) NA 34 (30–36) 33 (27–35)
Natremia (mmol l−1) NA 138 (133–141) 141 (138–144)
Glycemia (mmol l−1) NA 6.8 (6.8–9.6) 7.3 (5.8–8.6)
Temperature (°C) NA 37 (37.2–38.0) 37 (36.5–38)
Propofol 17 (100%) 11 (100%) 38 (100%)
Midazolam 0 7 (64%) 11 (29%)
Ketamine 0 0 8 (21%)
Fentanyl 0 9 (82%) 20 (53%)
Norepinephrine 0 7 (64%)c 24 (63%)d
Epinephrine 0 0 2 (5%)e
  1. Continuous values were expressed as median (25th–75th); discontinuous values were expressed with percentage
  2. SAPSII Simplified Acute Physiology Score, SOFA sequential organ failure assessment, NA non available, FL fluid loading, MAP mean arterial pressure, ETCO2 end-tidal CO2
  3. aSepsis group: 14/38 (37%) severe sepsis, 24/38 (63%) septic shock
  4. bD0 was the day of admission in ICU
  5. cMean dose 2.3 (0.7–2.8) mg h−1
  6. dMean dose 2.8 (0.7–3.5) mg h−1
  7. eMean dose 0.25 (0.2–0.29) µg kg−1 min−1
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