Skip to main content

Table 2 Systemic and cerebral hemodynamics

From: Impact of fluid challenge increase in cardiac output on the relationship between systemic and cerebral hemodynamics in severe sepsis compared to brain injury and controls

  Control
n = 17
Brain injury
n = 11
Sepsis
n = 38
p p
S versus C
p
BI versus C
p
S versus BI
Baseline
 CO (l min−1) 4.6 (3.4 to 6.5) 3.2 (2.8 to 3.5) 5.2 (4 to 6.7) 0.0036* 0.03* 0.015* 0.0006*
 SV (ml) 66 (54 to 86) 49 (33 to 53) 53 (41 to 72) 0.0087* 0.0302*  0.0023* 0.1188
 HR (min−1) 72 (62 to 80) 75 (65 to 89) 103 (87 to 123) < 0.0001* < 0.0001  0.2485 0.0028*
 SAP (mmHg) 105 (96 to 122) 128 (102 to 147) 101 (88 to 113) 0.0146* 0.1995  0.0515 0.0056*
 DAP (mmHg) 60 (53 to 75) 66 (60 to 79) 52 (46 to 57) 0.0001* 0.0036*  0.2890 < 0.0001*
 MAP (mmHg) 74 (65 to 89) 89 (77 to 96) 67 (56 to 75) 0.0007* 0.024*  0.0926 0.0002*
 PP (mmHg) 45 (37 to 51) 54 (40 to 78) 47 (36 to 62) 0.2404    
 PSV (cm s−1) 62 (51 to 70) 90 (55 to 122) 94 (66 to 107) 0.0068* 0.0006*  0.1950 0.6405
 EDV (cm s−1) 27 (20 to 34) 32 (24 to 43) 34 (26 to 39) 0.3031    
Fluid challenge
 ΔCO (%) 19 (13 to 31)* 22 (15 to 27)* 27 (17 to 33)* 0.2071    
 ΔSV (%) 26 (17 to 46)* 30 (24 to 33)* 27 (19 to 42)* 0.9671    
 ΔHR (%) − 6 (− 12 to 1)* − 6 (− 8 to − 1)* − 3 (− 8 to 0)* 0.2682    
 ΔSAP (%) 2 (− 2 to 5) 8 (3 to 27)* 12 (4 to 37)* 0.0022* 0.0006* 0.0278* 0.2935
 ΔDAP (%) 1 (− 6 to 8) 4 (− 2 to 27) 7 (0 to 14)* 0.1814    
 ΔMAP (%) 1 (− 4 to 5) 4 (1 to 13)* 12 (2 to 25)* 0.0026* 0.0007* 0.0511 0.1802
 ΔPP (%) 2 (− 6 to 7) 15 (2 to 29)* 22 (5 to 59)* 0.0026* 0.0005* 0.0904 0.2008
 ΔPSV (%) 2 (0 to 11) 6 (5 to 11)* 17 (3 to 30)* 0.0075* 0.0042* 0.2789 0.0552
 ΔEDV (%) 0 (− 7 to 8) 5 (0 to 16) 17 (12 to 42)* < 0.0001* < 0.0001* 0.3461 0.0170
  1. Quantitative values were expressed as median (25th–75th). Statistical tests: nonparametric tests, intragroup comparisons by Wilcoxon, intergroup by Kruskal–Wallis and Mann–Whitney test
  2. CO cardiac output, SV stroke volume, HR heart rate, SAP systolic arterial pressure, DAP diastolic arterial pressure, MAP mean arterial pressure, PP pulse pressure, PSV pic systolic velocity, EDV end diastolic velocity, C Control group, S septic group, BI brain injury group
\