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Annals of Intensive Care

Table 2 Systemic and cerebral hemodynamics

From: Impact of fluid challenge increase in cardiac output on the relationship between systemic and cerebral hemodynamics in severe sepsis compared to brain injury and controls

 

Control

n = 17

Brain injury

n = 11

Sepsis

n = 38

p

p

S versus C

p

BI versus C

p

S versus BI

Baseline

 CO (l min−1)

4.6 (3.4 to 6.5)

3.2 (2.8 to 3.5)

5.2 (4 to 6.7)

0.0036*

0.03*

0.015*

0.0006*

 SV (ml)

66 (54 to 86)

49 (33 to 53)

53 (41 to 72)

0.0087*

0.0302* 

0.0023*

0.1188

 HR (min−1)

72 (62 to 80)

75 (65 to 89)

103 (87 to 123)

< 0.0001*

< 0.0001 

0.2485

0.0028*

 SAP (mmHg)

105 (96 to 122)

128 (102 to 147)

101 (88 to 113)

0.0146*

0.1995 

0.0515

0.0056*

 DAP (mmHg)

60 (53 to 75)

66 (60 to 79)

52 (46 to 57)

0.0001*

0.0036* 

0.2890

< 0.0001*

 MAP (mmHg)

74 (65 to 89)

89 (77 to 96)

67 (56 to 75)

0.0007*

0.024* 

0.0926

0.0002*

 PP (mmHg)

45 (37 to 51)

54 (40 to 78)

47 (36 to 62)

0.2404

   

 PSV (cm s−1)

62 (51 to 70)

90 (55 to 122)

94 (66 to 107)

0.0068*

0.0006* 

0.1950

0.6405

 EDV (cm s−1)

27 (20 to 34)

32 (24 to 43)

34 (26 to 39)

0.3031

   

Fluid challenge

 ΔCO (%)

19 (13 to 31)*

22 (15 to 27)*

27 (17 to 33)*

0.2071

   

 ΔSV (%)

26 (17 to 46)*

30 (24 to 33)*

27 (19 to 42)*

0.9671

   

 ΔHR (%)

− 6 (− 12 to 1)*

− 6 (− 8 to − 1)*

− 3 (− 8 to 0)*

0.2682

   

 ΔSAP (%)

2 (− 2 to 5)

8 (3 to 27)*

12 (4 to 37)*

0.0022*

0.0006*

0.0278*

0.2935

 ΔDAP (%)

1 (− 6 to 8)

4 (− 2 to 27)

7 (0 to 14)*

0.1814

   

 ΔMAP (%)

1 (− 4 to 5)

4 (1 to 13)*

12 (2 to 25)*

0.0026*

0.0007*

0.0511

0.1802

 ΔPP (%)

2 (− 6 to 7)

15 (2 to 29)*

22 (5 to 59)*

0.0026*

0.0005*

0.0904

0.2008

 ΔPSV (%)

2 (0 to 11)

6 (5 to 11)*

17 (3 to 30)*

0.0075*

0.0042*

0.2789

0.0552

 ΔEDV (%)

0 (− 7 to 8)

5 (0 to 16)

17 (12 to 42)*

< 0.0001*

< 0.0001*

0.3461

0.0170

  1. Quantitative values were expressed as median (25th–75th). Statistical tests: nonparametric tests, intragroup comparisons by Wilcoxon, intergroup by Kruskal–Wallis and Mann–Whitney test
  2. CO cardiac output, SV stroke volume, HR heart rate, SAP systolic arterial pressure, DAP diastolic arterial pressure, MAP mean arterial pressure, PP pulse pressure, PSV pic systolic velocity, EDV end diastolic velocity, C Control group, S septic group, BI brain injury group
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