|
Age (years), mean (SD)
|
67 (14)
|
66 (13)
|
|
Female gender, n (%)
|
200 (33.9)
|
202 (34.6)
|
|
BMI (kilograms divided by height in metres squared), mean (SD)
|
26.7 (6.6)
|
27.4 (7.1)
|
|
Chronic alcohol use, n (%)
|
115 (19.5)
|
126 (21.6)
|
|
Chronic psychotropic medication use, n (%)
|
177 (30.0)
|
166 (28.4)
|
|
Benzodiazepine and related medications
|
110 (18.6)
|
109 (18.7)
|
|
Neuroleptics
|
22 (3.7)
|
33 (5.7)
|
|
Antidepressants
|
72 (12.2)
|
70 (12.0)
|
|
Opioid medication
|
42 (7.1)
|
35 (6.0)
|
|
Tobacco use, n (%)
|
156 (26.5)
|
169 (28.9)
|
|
Liver cirrhosis with ascites or oesophageal varices, n (%)
|
34 (5.8)
|
37 (6.3)
|
|
Chronic renal replacement therapy, n (%)
|
9 (1.5)
|
10 (1.7)
|
|
Chronic respiratory insufficiency with home oxygen therapy, n (%)
|
42 (7.1)
|
51 (8.7)
|
|
NYHA class IV chronic heart failure, n (%)
|
16 (2.7)
|
23 (3.9)
|
|
Barthel score before admission, median (Q1–Q3)
|
100 (100–100)
|
100 (95–100)
|
|
Knauss chronic health status before admission, n (%)
|
|
Normal health status
|
155 (26.3)
|
152 (26.0)
|
|
Moderate activity limitation
|
285 (48.3)
|
267 (45.7)
|
|
Severe activity limitation due to chronic disease
|
139 (23.6)
|
157 (26.9)
|
|
Bedridden patient
|
11 (1.9)
|
8 (1.4)
|
|
MacCabe class before admission, n (%)
|
|
No fatal disease
|
363 (61.5)
|
348 (59.6)
|
|
Ultimately fatal disease
|
181 (30.7)
|
197 (33.7)
|
|
Rapidly fatal disease
|
46 (7.8)
|
39 (6.7)
|
|
At home without assistance before current hospital admission, n (%)
|
373 (63.2)
|
367 (62.8)
|
|
ICU admission SAPS II score (first 24 h), mean (SD)
|
54.4 (18.6)
|
53.6 (17.8)
|
|
ICU admission SOFA score (first 24 h), median (Q1–Q3)
|
9 (7–12)
|
9 (7–12)
|
|
Medical admission, n (%)
|
520 (88.1)
|
530 (90.8)
|
|
Norepinephrine at randomization, n (%)
|
312 (53.0)
|
318 (54.5)
|
|
Midazolam at randomization (n1 = 493, n2 = 496), n (%)
|
412 (83.6)
|
421 (84.9)
|
|
Propofol at randomization (n1 = 493, n2 = 496), n (%)
|
74 (15.0)
|
69 (13.9)
|
|
Severe sepsis, n (%)
|
50 (8.5)
|
57 (9.8)
|
|
Septic shock, n (%)
|
339 (57.5)
|
323 (55.3)
|
|
ARDS, n (%)
|
186 (31.5)
|
187 (32.1)
|
|
ICU primary diagnosis
|
|
Pulmonary infection, n (%)
|
246 (41.7)
|
239 (40.9)
|
|
Abdominal infection, n (%)
|
49 (8.3)
|
54 (9.3)
|
|
Other Infection, n (%)
|
41 (6.9)
|
57 (9.8)
|
|
Cardiac failure or cardiogenic pulmonary oedema, n (%)
|
56 (9.5)
|
53 (9.1)
|
|
COPD exacerbation or acute asthma, n (%)
|
51 (8.6)
|
51 (8.7)
|
|
Acute pancreatitis, n (%)
|
9 (1.5)
|
13 (2.2)
|
|
Drug intoxication, n (%)
|
12 (2.0)
|
9 (1.5)
|
|
Metabolic disorder, n (%)
|
18 (3.1)
|
7 (1.2)
|
|
Trauma, n (%)
|
7 (1.2)
|
7 (1.2)
|
|
Acute stroke, n (%)
|
5 (0.8)
|
2 (0.3)
|
|
Miscellaneous, n (%)
|
96 (16.3)
|
92 (15.8)
|
|
Sedation level on the RASS scale at randomizationa
|
|
Very agitated, n (%)
|
1 (0.4)
|
3 (1.1)
|
|
Agitated, n (%)
|
4 (1.5)
|
1 (0.4)
|
|
Restless, n (%)
|
3 (1.1)
|
5 (1.9)
|
|
Alert and calm, n (%)
|
12 (4.5)
|
12 (4.6)
|
|
Drowsy, n (%)
|
12 (4.5)
|
12 (4.6)
|
|
Light sedation, n (%)
|
21 (7.9)
|
15 (5.7)
|
|
Moderate sedation, n (%)
|
30 (11.3)
|
23 (8.8)
|
|
Deep sedation, n (%)
|
63 (23.8)
|
66 (25.2)
|
|
Unarousable, n (%)
|
119 (44.9)
|
125 (47.7)
|
