28-day mortality
|
198 (33.6)
|
177 (30.4)
|
0.24a
| |
90-day mortality
|
261 (44.2)
|
230 (39.4)
|
0.09a
| |
1-year mortality
|
296 (60.0)
|
267 (56.5)
|
0.26a
| |
Mechanical ventilation-free days at day 28 (days), median (Q1–Q3)
|
14 (0–24)
|
16 (0-24)
|
0.36b
| |
Ventilator-associated pneumonia, n
|
92
|
94
|
0.79c
|
1.04 (0.78; 1.38)
|
Mechanical ventilation ≥ 48 h, n (%)
|
425 (72.0)
|
418 (71.6)
|
0.86a
| |
Non-invasive ventilation after extubation, n (%)
|
152 (25.8)
|
177 (30.3)
|
0.08a
| |
Duration of non-invasive ventilation after extubation (days), median (Q1–Q3)
|
2 (1–4)
|
3 (2–4)
|
0.05b
| |
Tracheostomy, n
|
26
|
24
|
0.81c
|
0.93 (0.54; 1.62)
|
Delirium, n
|
232
|
230
|
0.99c
|
1.00 (0.84; 1.19)
|
Proximal weakness after awakening, n
|
193
|
208
|
0.26c
|
1.11 (0.92; 1.35)
|
Patients with intravenous midazolam, n (%)
|
464 (78.6)
|
419 (71.8)
|
0.01a
| |
Cumulative dosage of midazolam (mg), median (Q1–Q3)
|
263 (120–660)
|
218 (72–696)
|
0.03b
| |
Patients with intravenous propofol, n (%)
|
232 (39.3)
|
214 (36.6)
|
0.34a
| |
Cumulative dosage of propofol (mg), median (Q1–Q3)
|
2785 (645–7140)
|
1443 (120–4800)
|
< 0.001b
| |
Patients with intravenous morphinics, n (%)
|
501 (84.9)
|
482 (82.5)
|
0.31a
| |
Patients with IV sufentanil, n (%)
|
263 (44.6)
|
241 (41.3)
|
0.28a
| |
Cumulative dosage of sufentanil (µg), median (Q1–Q3)
|
930 (472–2592)
|
870 (280-2160)
|
0.04b
| |
Patients with IV fentanyl, n (%)
|
204 (34.6)
|
206 (35.3)
|
0.8a
| |
Cumulative dosage of fentanyl (µg), median (Q1–Q3)
|
4985 (2400–15,445)
|
4656 (1340–16,200)
|
0.29b
| |
Patients with IV morphine, n (%)
|
73 (12.4)
|
91 (15.6)
|
0.1a
| |
Cumulative dosage of morphine (mg), median (Q1–Q3)
|
17.5 (7–55)
|
20 (6–43)
|
0.69b
| |
Patients with IV remifentanil, n (%)
|
49 (8.3)
|
45 (7.7)
|
0.7a
| |
Cumulative dosage of remifentanil (µg), median (Q1–Q3)
|
14,400 (6000–28,800)
|
7200 (3000-19,200)
|
0.05b
| |
Self-extubation, n
|
48
|
70
|
0.03c
|
1.50 (1.04; 2.16)
|
Ventricular tachycardia or fibrillation, n
|
18
|
21
|
0.61c
|
1.18 (0.63; 2.11)
|
Acute coronary syndrome or myocardial infarction, n
|
7
|
8
|
0.77c
|
1.16 (0.42; 3.18)
|
Cardiac arrest, n
|
20
|
13
|
0.22c
|
0.65 (0.33; 1.31)
|