Control (n = 590) | Oversedation prevention (n = 584) | P value | Hazard ratio (95% confidence interval) | |
---|---|---|---|---|
28-day mortality | 198 (33.6) | 177 (30.4) | 0.24a | |
90-day mortality | 261 (44.2) | 230 (39.4) | 0.09a | |
1-year mortality | 296 (60.0) | 267 (56.5) | 0.26a | |
Mechanical ventilation-free days at day 28 (days), median (Q1–Q3) | 14 (0–24) | 16 (0-24) | 0.36b | |
Ventilator-associated pneumonia, n | 92 | 94 | 0.79c | 1.04 (0.78; 1.38) |
Mechanical ventilation ≥ 48 h, n (%) | 425 (72.0) | 418 (71.6) | 0.86a | |
Non-invasive ventilation after extubation, n (%) | 152 (25.8) | 177 (30.3) | 0.08a | |
Duration of non-invasive ventilation after extubation (days), median (Q1–Q3) | 2 (1–4) | 3 (2–4) | 0.05b | |
Tracheostomy, n | 26 | 24 | 0.81c | 0.93 (0.54; 1.62) |
Delirium, n | 232 | 230 | 0.99c | 1.00 (0.84; 1.19) |
Proximal weakness after awakening, n | 193 | 208 | 0.26c | 1.11 (0.92; 1.35) |
Patients with intravenous midazolam, n (%) | 464 (78.6) | 419 (71.8) | 0.01a | |
Cumulative dosage of midazolam (mg), median (Q1–Q3) | 263 (120–660) | 218 (72–696) | 0.03b | |
Patients with intravenous propofol, n (%) | 232 (39.3) | 214 (36.6) | 0.34a | |
Cumulative dosage of propofol (mg), median (Q1–Q3) | 2785 (645–7140) | 1443 (120–4800) | < 0.001b | |
Patients with intravenous morphinics, n (%) | 501 (84.9) | 482 (82.5) | 0.31a | |
Patients with IV sufentanil, n (%) | 263 (44.6) | 241 (41.3) | 0.28a | |
Cumulative dosage of sufentanil (µg), median (Q1–Q3) | 930 (472–2592) | 870 (280-2160) | 0.04b | |
Patients with IV fentanyl, n (%) | 204 (34.6) | 206 (35.3) | 0.8a | |
Cumulative dosage of fentanyl (µg), median (Q1–Q3) | 4985 (2400–15,445) | 4656 (1340–16,200) | 0.29b | |
Patients with IV morphine, n (%) | 73 (12.4) | 91 (15.6) | 0.1a | |
Cumulative dosage of morphine (mg), median (Q1–Q3) | 17.5 (7–55) | 20 (6–43) | 0.69b | |
Patients with IV remifentanil, n (%) | 49 (8.3) | 45 (7.7) | 0.7a | |
Cumulative dosage of remifentanil (µg), median (Q1–Q3) | 14,400 (6000–28,800) | 7200 (3000-19,200) | 0.05b | |
Self-extubation, n | 48 | 70 | 0.03c | 1.50 (1.04; 2.16) |
Ventricular tachycardia or fibrillation, n | 18 | 21 | 0.61c | 1.18 (0.63; 2.11) |
Acute coronary syndrome or myocardial infarction, n | 7 | 8 | 0.77c | 1.16 (0.42; 3.18) |
Cardiac arrest, n | 20 | 13 | 0.22c | 0.65 (0.33; 1.31) |