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Table 2 Evolution of the clinical characteristics and illness severity scores of patients according to lactate level (≤ 2 or > 2 mmol/L) and normoxia or hyperoxia treatment

From: Hyperoxia toxicity in septic shock patients according to the Sepsis-3 criteria: a post hoc analysis of the HYPER2S trial

  Lactate ≤ 2 mmol/L (n = 167) Lactate > 2 mmol/L (n = 230)
Normoxia (n = 75) Hyperoxia (n = 92) p value Normoxia (n = 122) Hyperoxia (n =T108) p value
Mortality at d28 17 (22.7%) 23 (25.0%) 0.680¥ 54 (44.3%) 62 (57.4%) 0.054¥
Mortality at d90¥ 21 (28.0%) 30 (32.6%) 0.513¥ 63 (51.6%) 64 (59.3%) 0.171¥
RRT 14 (18.9%) 25 (27.8%) 0.185 50 (42.7%) 44 (41.5%) 0.853
Days without vasopressor, mean (SD) 21 (10) 19 (9) 0.323 14 (12) 12 (12) 0.149
Days without mechanical ventilation, mean (SD) 16 (9) 13 (10) 0.04 11 (11) 9 (11) 0.131
Days without RRT, mean (SD) 24 (9) 22 (10) 0.12 16 (12) 13 (12) 0.139
Survival at day 28 without organ support, n (%) 54 (73.0%) 61 (67.8%) 0.47 58 (49.6%) 41 (38.7%) 0.102
SOFA h0
  Mean (SD) 9.5 (2.5) 9.6 (2.4) 0.851 10.6 (2.9) 10.6 (2.8) 0.987
  Median (IQR) 9 (8–11) 9 (8–11) 0.782 11 (8–12) 11 (8–12) 0.85
  n 75 92   122 108  
SOFA h24
  Mean (SD) 9.4 (2.6) 9.8 (3) 0.273 11.9 (3.3) 11.6 (3.4) 0.526
  Median (IQR) 9 (7–11) 9 (8–12) 0.335 11 (10–14) 12 (9–14) 0.693
  n 75 89   112 104  
SOFA h48
  Mean (SD) 7.8 (3.3) 9.6 (3.6) 0.001 10.8 (4.1) 10.8 (3.6) 0.962
  Median (IQR) 7 (6–10) 9 (7–12) 0.002 10 (8–14) 10 (9–14) 0.99
  n 71 82   93 80  
SOFA h72
  Mean (SD) 6.6 (3.9) 8.4 (4.4) 0.008 9.9 (4.6) 9.2 (4.4) 0.374
  Median (IQR) 6 (4–9) 8 (5–11) 0.014 10 (6.8–13) 9 (6–13) 0.43
  n 65 82   88 71  
SOFA d4
  Mean (SD) 6.3 (4.2) 6.9 (4.4) 0.436 8 (4.7) 6.9 (3.8) 0.136
  Median (IQR) 5 (3–8) 6 (4–10) 0.396 7 (4–11) 7 (4–9) 0.29
  n 53 67   69 57  
SOFA d5
  Mean (SD) 5.9 (3.9) 6.1 (3.9) 0.815 8.3 (4.8) 6.4 (3.9) 0.024
  Median (IQR) 5.5 (3–8) 5 (3–8) 0.819 7 (5–11) 6 (4–9) 0.044
  n 44 63   62 51  
SOFA d6
  Mean (SD) 5.5 (3.8) 5.8 (3.9) 0.704 7.8 (4.8) 6.4 (4) 0.108
  Median (IQR) 6 (3–7) 4 (3–9) 0.695 7 (4.5–10) 5.5 (3–9) 0.155
  n 37 55   59 44  
SOFA d7
  Mean (SD) 5.4 (3.6) 5.8 (4.2) 0.726 8.1 (5) 4.9 (3.4) 0.001
  Median (IQR) 5 (3–7) 5 (3–8) 1 7 (4–10.2) 4 (2–7) 0.002
  n 29 47   48 34  
PaO2 h0
  Mean (SD) 148.4 (95.1) 126.4 (63.8) 0.09 170 (105) 151.1 (82.9) 0.139
  Median (IQR) 116 (92–172) 113 (85–144) 0.289 139 (90–202) 130 (93–184) 0.295
  n 75 92   122 108  
PaO2 h12
  Mean (SD) 97.1 (29.4) 265.4 (119) < 0.0001 105.8 (44.9) 274.6 (136) < 0.0001
  Median (IQR) 89 (75–117) 273 (172–367) < 0.0001 96 (70–124) 277 (158–364) < 0.0001
  n 69 86   109 103  
PaO2 h24
  Mean (SD) 89.3 (27.7) 221.3 (115.8) < 0.0001 101.0 (46.2) 229.8 (131.8) < 0.0001
  Median (IQR) 82 (73–98.5) 211 (133–295) < 0.0001 91 (77–109.2) 210.5 (119.8–322.8) < 0.0001
  n 67 83   100 92  
PaO2 h72
  Mean (SD) 88.9 (24.7) 96.5 (54.6) 0.306 88.6 (25.2) 92.4 (29.4) 0.431
  Median (IQR) 84 (71–101) 82 (74–107) 0.801 84.5 (71.8–96.8) 86 (74–98) 0.481
  n 55 69   72 61  
  1. For mortality at day 28 and 90, respectively, an analysis in landmark with a log-rank test was used. For survival at day 28 without organ support and/or renal replacement therapy (RRT) a χ2 test was used. For the number of days without vasopressor therapy, without mechanical ventilation, and without RRT, respectively, a Student’s t test was used. ¥ = log-rank test; for mortality at day 28 in patients with a lactate > 2 mmol/L: χ2 test; d day, h hour