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Table 3 Data analysis by using a Cox regression model with survival data censored at 28 days and then censored at 90 days in succession

From: Hyperoxia toxicity in septic shock patients according to the Sepsis-3 criteria: a post hoc analysis of the HYPER2S trial

 

Inclusion d28

Inclusion d90

HR

95% CI

p value

HR

95%CI

p value

Univariate Cox model (universal analysis)

  Sex (F vs M)

1.59

1.12

2.24

0.013

1.51

1.06

2.14

0.021

  Weight (per 10 kg increase)

1

0.89

1.13

0.999

1.04

0.93

1.16

0.503

  pH (per 0.1 increase)

0.97

0.95

0.98

< 0.001

0.97

0.95

0.98

< 0.001

  Hyperoxia vs normoxia

1.44

1.00

2.07

0.051

1.28

0.91

1.82

0.160

  SAPS 2

1.05

1.03

1.06

< 0.001

1.05

1.04

1.06

< 0.001

  Mac Cabe

1.25

0.97

1.62

0.089

1.25

0.98

1.61

0.073

  PaO2/FiO2

1

0.99

1.00

0.860

1

0.99

1.00

0.660

  Autoimmune disease

1.17

0.76

1.80

0.480

1.262

0.84

1.89

0.260

Multivariate Cox model

  Sex (F vs M)

1.55

1.06

2.27

0.022

1.53

1.06

2.22

0.024

  pH (per 0.1 increase)

0.96

0.95

0.98

< 0.001

0.97

0.95

0.98

< 0.001

  Hyperoxia vs normoxia

1.79

1.21

2.63

0.003

1.57

1.09

2.28

0.016

  SAPS 2

1.05

1.04

1.06

< 0.001

1.05

1.04

1.06

< 0.001

  Mac Cabe

1.07

0.82

1.39

0.613

1.06

0.83

1.37

0.640

  1. HR hazard ratio, CI confidence interval, F female, M male