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Table 3 Data analysis by using a Cox regression model with survival data censored at 28 days and then censored at 90 days in succession

From: Hyperoxia toxicity in septic shock patients according to the Sepsis-3 criteria: a post hoc analysis of the HYPER2S trial

  Inclusion d28 Inclusion d90
HR 95% CI p value HR 95%CI p value
Univariate Cox model (universal analysis)
  Sex (F vs M) 1.59 1.12 2.24 0.013 1.51 1.06 2.14 0.021
  Weight (per 10 kg increase) 1 0.89 1.13 0.999 1.04 0.93 1.16 0.503
  pH (per 0.1 increase) 0.97 0.95 0.98 < 0.001 0.97 0.95 0.98 < 0.001
  Hyperoxia vs normoxia 1.44 1.00 2.07 0.051 1.28 0.91 1.82 0.160
  SAPS 2 1.05 1.03 1.06 < 0.001 1.05 1.04 1.06 < 0.001
  Mac Cabe 1.25 0.97 1.62 0.089 1.25 0.98 1.61 0.073
  PaO2/FiO2 1 0.99 1.00 0.860 1 0.99 1.00 0.660
  Autoimmune disease 1.17 0.76 1.80 0.480 1.262 0.84 1.89 0.260
Multivariate Cox model
  Sex (F vs M) 1.55 1.06 2.27 0.022 1.53 1.06 2.22 0.024
  pH (per 0.1 increase) 0.96 0.95 0.98 < 0.001 0.97 0.95 0.98 < 0.001
  Hyperoxia vs normoxia 1.79 1.21 2.63 0.003 1.57 1.09 2.28 0.016
  SAPS 2 1.05 1.04 1.06 < 0.001 1.05 1.04 1.06 < 0.001
  Mac Cabe 1.07 0.82 1.39 0.613 1.06 0.83 1.37 0.640
  1. HR hazard ratio, CI confidence interval, F female, M male