Table 2 Performance of SAP-guided resuscitation with fluid and with combination of fluid and norepinephrine

226 (173–412)

252 (224–504)

529 (192–1141)

0.466

434 (254–1081)

160 (106–187)

< 0.001

76.8 (67.9–78.2)

80.9 (59.1–85.3)

64.6 (45.7–72.9)

0.160

60.1 (46.1–72.4)

74.4 (58.4–84.5)

0.199

21.3 (16.8–23.7)

18.6 (13.9–33.6)

29.8 (17.7–35.2)

0.481

34.5 (13.1–43.5)

12.4 (6.4–22.8)

0.139

1.3 (0–8.7)

0 (0–2.5)

3.1 (0.1–28.1)

0.155

3.3 (0.5–18.3)

4.9 (3.3–17.7)

0.436

− 2.6 (− 3.5 to − 1.7)

− 3.5 (− 5.3 to − 0.6)

− 3.5 (− 4.7 to − 2.1)

0.729

− 2.8 (− 4.9 to − 1.9)

− 3.5 (− 3.5 to 0.6)

0.587

3.6 (3.1–4.6)

3.5 (2.9–5.3)

4.7 (4.4–7.4)

0.071

4.5 (3.4–6.3)

3.5 (2.9–5.9)

0.587

2.9 (2–3.7)

2.4 (1.8–3.5)

2.9 (2.4–7.1)

0.227

3.3 (2.9–4.2)

2.4 (1.8–4.1)

0.264

8 (6.8–12.4)

8.3 (5.5–16)

13.4 (9.4–31.9)

0.123

13 (9–23.1)

7 (5.7–17.5)

0.277

29.5 (24.5–38)

1159 (792.5–1382)^†

37.8 (19–52)

< 0.001

20 (16–31.5)

55 (30–112)

0.002