Table 2 Symptoms, signs, and elements of clinical history suggestive of STSS frequently reported among literature

Context of recent trauma, surgical intervention, skin lesion or NSAID intake

Prodromal influenza-like symptoms

Digestive symptoms (vomiting, diarrhea, abdominal pain)

Severe pain, out of proportion is frequent, in the absence of evident portal of entry

Signs of soft tissue infection (necrotizing fasciitis, gangrene, myositis, etc.)

Generalized erythematous macular rash (early)

Palmar and plantar desquamation (late)

Multiple organ failure including two or more of the following: renal impairment, coagulopathy, liver involvement, acute respiratory distress syndrome