Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning

Annals of Intensive Care

Table 3 Cox regression analysis of clinical variables associated with 60-day mortality in influenza pneumonia-related ARDS with prone positioning

Clinical variables	Univariate		Multivariate
Clinical variables	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
APACHE II score	1.089 (1.035–1.147)	0.001*	1.042 (0.982–1.106)	0.178
PSI	1.015 (1.005–1.026)	0.003*	1.020 (1.009–1.032)	< 0.001*
Renal replacement therapy	5.355 (2.159–13.281)	0.000*	6.248 (2.245–17.389)	< 0.001*
Δ Peak airway pressure (cm H₂O)	1.143 (1.019–1.282)	0.022*	0.996 (0.822–1.208)	0.969
Δ Dynamic driving pressure (cm H₂O)	1.147 (1.008–1.305)	0.037*	1.372 (1.095–1.718)	0.006*
Δ Dynamic compliance (ml/cm H₂O)	0.925 (0.871–0.983)	0.011*	0.941 (0.872–1.015)	0.117

ARDS acute respiratory distress syndrome, CI confidence interval, APACHE II Acute Physical and Chronic Health Evaluation, PSI pneumonia severity index, Δ difference between before and after prone positioning 1 day
*p < 0.05