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Annals of Intensive Care

Table 3 Multivariable logistic regression analyzing intensive care unit mortality and the longest episode of hypotension time below threshold of 65 mmHg

From: Mean arterial pressure and mortality in patients with distributive shock: a retrospective analysis of the MIMIC-III database

Parameter

Estimate

Standard error

Wald Chi-square

Pr > ChiSq

Odds ratio

Intercept

− 3.39

0.23

219.19

< 0.0001

0.03

MAP at initiation of vasopressors (vs. ≥ 65 mmHg)

     

 < 65 mmHg

0.15

0.07

4.29

0.0384

1.16

 Missing

− 0.36

0.16

5.10

0.024

0.70

Longest episode with MAP < 65 mmHg (vs. never below), hours

     

 > 0 to < 2

0.57

0.20

7.88

0.005

1.76

 ≥ 2 to < 4

0.66

0.20

10.38

0.0013

1.93

 ≥ 4 to < 6

0.80

0.21

14.19

0.0002

2.23

 ≥ 6 to < 8

1.06

0.23

22.15

< 0.0001

2.90

 ≥ 8 to < 10

1.24

0.25

25.04

< 0.0001

3.44

 ≥ 10 to < 12

1.47

0.27

29.19

< 0.0001

4.36

 ≥ 12 to < 16

1.67

0.26

40.46

< 0.0001

5.30

 ≥ 16 to < 20

1.70

0.32

27.87

< 0.0001

5.47

 ≥ 20

1.96

0.28

49.20

< 0.0001

7.10

Max catecholamine dose (vs. 0 to < 0.2), NED

     

 ≥ 0.2 to < 0.5

0.64

0.09

50.58

< 0.0001

1.89

 ≥ 0.5 to < 1.0

1.44

0.10

195.55

< 0.0001

4.24

 ≥ 1.0 to < 1.5

1.85

0.14

174.34

< 0.0001

6.37

 ≥ 1.5 to < 2.0

2.07

0.24

73.03

< 0.0001

7.95

 ≥ 2.0 to < 2.5

2.08

0.31

45.37

< 0.0001

7.97

 ≥ 2.5

1.61

0.20

63.21

< 0.0001

4.99

Age (vs. < 65), years

     

 65–74

0.33

0.09

12.48

0.0004

1.39

 75–84

0.48

0.09

28.23

< 0.0001

1.62

 ≥ 85

0.73

0.11

44.40

< 0.0001

2.07

Female (vs. male)

− 0.07

0.07

0.92

0.3364

0.94

Severe sepsis/septic shock (vs. none)

− 0.19

0.08

5.44

0.0197

0.83

SOFA score (vs. ≤ 4)

     

 > 4 to ≤ 6

0.03

0.11

0.07

0.7851

1.03

 > 6 to ≤ 8

0.09

0.11

0.58

0.4447

1.09

 > 8 to ≤ 10

0.32

0.12

6.75

0.0094

1.37

 > 10

1.09

0.12

83.90

< 0.0001

2.98

Hypertension (vs. none)

− 0.02

0.08

0.09

0.7674

0.98

Baseline mechanical ventilation (vs. none)

0.15

0.07

4.45

0.035

1.16

Baseline continuous renal replacement therapy (vs. none)

1.26

0.38

11.19

0.0008

3.54

Albumin level (vs. ≥ 2.5 g/dL)

     

 < 2.5 g/dL

0.60

0.11

29.41

< 0.0001

1.83

 Missing

0.18

0.08

5.01

0.0252

1.20

Creatinine level (vs. < 2.0 mg/dL)

     

 ≥ 2.0 mg/dL

− 0.09

0.08

1.14

0.2863

0.92

 Missing

− 0.55

0.17

10.07

0.0015

0.57

Lactate level (vs. < 2.0 mmol/L)

     

 ≥ 2.0 mmol/L

0.38

0.08

20.66

< 0.0001

1.46

 Missing

0.37

0.10

14.90

0.0001

1.45

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