Table 1 Characteristics, details of interventions used and outcomes measured in randomized trials studying albumin treatment during spontaneous bacterial peritonitis, sepsis other than SBP in cirrhotic patients and general ICU population with sepsis
From: Albumin infusion in spontaneous bacterial peritonitis: another brick off the wall?
Trial | N | Age, ya | Experimental treatment | Control treatment | Mortality (albumin vs. control group; p) |
|---|---|---|---|---|---|
Spontaneous bacterial peritonitis | |||||
Sort et al. [8] | 126 | 61.0 (7.9) | 20% albumin | No vascular filling | Favors albumin (22% vs. 41%; p = 0.03)b |
Xue et al. [10] | 112 | 22–70 | 20% albumin | No vascular filling | Favors albumin (10% vs. 34%; p = 0.002)c |
Fernandez et al. [14] | 20 | 61.0 (9.5) | 20% albumin | 6% HES 200/0.5 | NS (not significant) (0% vs. 20%; p = 0.47)c |
Chen et al. [11] | 30 | 56.5 (11.5) | 20% albumin | No vascular filling | NS (26.7% vs. 40%; p = 0.70)c |
Sepsis other than SBP in cirrhotic patients (no septic shock) | |||||
Guevara et al. [15] | 97 | 56 (11) | 20% albumin | No vascular filling | NS (17% vs. 20%; p = 0.78)b |
Thévenot et al. [16] | 193 | 55.3 (8.6) | 20% albumin | No vascular filling | NS (30% vs. 22%; p = 0,16)b |
Sepsis and septic shock in general ICU population d | |||||
SAFE study [2]e | 1218 | 60.5 (17.2) | 4% albumin | NaCl 0.9% | NS (30.7% vs. 35.3%; p = 0.09)f |
ALBIOS study [3] | 1810 | 69 [59–77] | 20% albumin | Crystalloids | NS (20.9% vs. 21.1%; p = 0.87)f |