From: Artificial liver support systems: what is new over the last decade?
Study | Years | Design | Patients number | Outcomes | Comments | LOE |
---|---|---|---|---|---|---|
Rusu et al. [59] | 2009 | Uncontrolled, retrospective | 27 | Improvement in HE in ALF** | Haemodynamic improvement in patients with liver failure post-transplantation** | 3 |
 |  |  |  | No clinical improvement in AoCLF |  |  |
Stutchfield et al. [54] | 2011 | Systematic review | 8 RCT | ELS improved survival in ALF** | Independent meta-analysis for trials including patients with ALF or AoCLF | 2 |
 |  |  |  | No statistically significant reduction in mortality in AoCLF | 3 trials using bioartificial devices included |  |
Vaid et al. [52] | 2012 | Meta-analysis | 9 RCT 1 NRS | Improvement in HE* | No significant differences in subgroups (by age or MARS number sessions) | 2 |
 |  |  |  | No statistically significant reduction in overall mortality | Safety data no meta-analyzed |  |
Cisneros-Garza et al. [60] | 2014 | Uncontrolled, retrospective | 70 | Improvement in HE* | Patients with cholestasis disease were included. MARS associated with improved itching | 3 |
Tsipotis et al. [53] | 2015 | Meta-analysis | 10 RCT | Improvement in HE* | No significant differences in subgroups (by number of sessions or type of albumin dialysis technique) | 2 |
 |  |  |  | No statistically significant reduction in overall mortality | 3 trials used Prometheus |  |
Guo-Lin He et al. [55] | 2015 | Systematic review | 10 RCT | Reduction in mortality in ALF** | Independent meta-analysis for trials including patients with ALF or AoCLF | Â |
 |  |  |  | No statistically significant reduction in mortality in AoCLF | Very few patients with ALF included | 2 |