Table 1 Characteristics of the population at baseline and within 24 h of ICU admission
From: Development and performance of a novel vasopressor-driven mortality prediction model in septic shock
Parameter | Total cohort (n = 5352) | Derivation cohort (n = 4033) | Validation cohort (n = 1319) | p |
|---|---|---|---|---|
Age (years) | 65.7 (56–75.3) | 65.7 (55.8–75.3) | 65.9 (56.4–75.1) | 0.79 |
Caucasian race | 4879 (91.2) | 3677 (91.2) | 1202 (91.1) | 0.49 |
Male sex | 3297 (61.6) | 2512 (62.2) | 785 (59.5) | 0.07 |
Body mass index (kg/m2) | 28.5 (24.4–33.7) | 28.5 (24.4–33.7) | 28.6 (24.3–33.8) | 0.88 |
Charlson comorbidity index | 6 (4–8) | 6 (4–8) | 6 (3–8) | 0.41 |
Heart failure | 999 (18.7) | 731 (18.1) | 268 (20.3) | 0.08 |
Diabetes mellitus, type II | 1561 (29.2) | 1196 (29.7) | 365 (27.7) | 0.17 |
Chronic kidney disease | 1216 (22.7) | 910 (22.6) | 306 (23.2) | 0.65 |
APACHE-III score (24 h) | 83 (67–103) | 83 (68–103) | 82 (66–102) | 0.39 |
SOFA score (24 h) | 9 (7–12) | 9 (7–12) | 9 (8–12) | 0.81 |
Peak lactate (mmol/L) | 4.4 (2.8–7.9) | 4.4 (2.8–8) | 4.3 (2.8–7.8) | 0.49 |
Invasive mechanical ventilation | 4381 (81.9) | 3283 (81.4) | 1098 (83.2) | 0.14 |
Acute kidney injury within 24 h | 4226 (82.9) | 3174 (82.5) | 1052 (83.9) | 0.28 |
Cumulative fluid balance (L) (h) | ||||
3 | 6.2 (2.9–10.4) | 6.2 (2.9–10.4) | 6.3 (3–10.4) | 0.32 |
6 | 7.1 (3.6–11.5) | 7 (3.6–11.5) | 7.3 (3.8–11.7) | 0.27 |
24 | 9.3 (5.4–14.9) | 9.6 (5.7–15.6) | 9.6 (5.8–15.6) | 0.23 |
ICU length of stay (days) | 3.8 (2–7.7) | 3.7 (2–7.7) | 3.9 (2.1–7.7) | 0.09 |
Hospital length of stay (days) | 11.1 (6.5–21.7) | 11 (6.5–21.5) | 11.6 (6.6–22.2) | 0.16 |
Peak 24-h vasopressor doses | ||||
Norepinephrine (mcg/kg/min) | 0.1 (0.16–0.25) | 0.1 (0.05–0.25) | 0.1 (0.05–0.25) | 0.53 |
NEE (mcg/kg/min) | 0.2 (0.1–0.32) | 0.2 (0.1–0.32) | 0.2 (0.1–0.32) | 0.82 |
Vasoactive medication scores | ||||
Log10NEE | − 0.7 (− 1, − 0.5) | − 0.7 (− 1, − 0.5) | − 0.7 (− 1, − 0.5) | 0.82 |
Log10VIS | 1.3 (1–1.5) | 1.2 (1–1.5) | 1.2 (1–1.5) | 0.95 |
Log10CVI | 0.7 (0.6–0.9) | 0.7 (0.6–0.9) | 0.8 (0.6–0.9) | 0.25 |
≥ 2 vasoactive medications | 3245 (60.6) | 2412 (60.5) | 833 (60.9) | 0.80 |
28-day mortality | 2416 (45.1) | 1842 (45.7) | 574 (43.5) | 0.18 |
One-year mortality | 2660 (49.7) | 2026 (50.2) | 634 (48.1) | 0.17 |