Development and performance of a novel vasopressor-driven mortality prediction model in septic shock

Annals of Intensive Care

Table 3 28-day mortality predictors in the derivation cohort

Parameter	Univariable analysis		Multivariable analysis		MAVIC model
Parameter	OR (95% CI)^a	p	OR (95% CI)^a	p	OR (95% CI)^a	p
Age	1.1 (1.1–1.1)	< 0.001	1.0 (0.9–1.0)	0.88	–	–
Male sex	0.8 (0.7–0.9)	0.001	0.9 (0.8–0.9)	0.03	–	–
BMI (kg/m²)	0.9 (0.9–0.9)	0.02	0.9 (0.9–0.9)	< 0.001	–	–
CCI	1.2 (1.2–1.2)	< 0.001	1.2 (1.1–1.2)	< 0.001	1.1 (1.1–1.2)	< 0.001
APACHE-III score	1.1 (1.1–1.1)	< 0.001	1.1 (1.1–1.1)	< 0.001	1.1 (1.1–1.1)	< 0.001
Peak lactate (mmol/L)	1.1 (1.1–1.1)	< 0.001	1.1 (1.1–1.1)	< 0.001	–	–
Acute kidney injury	2.1 (1.7–2.5)	< 0.001	1.9 (1.6–2.3)	< 0.001	–	–
IMV	1.6 (1.4–1.9)	< 0.001	1.8 (1.5–2.2)	< 0.001	1.8 (1.5–2.2)	< 0.001
24-h cumulative fluids	1.0 (0.9–1.0)	0.77	–	–	–	–
Log₁₀24-h peak NEE	2.3 (2.1–2.6)	< 0.001	1.6 (1.4–1.9)	< 0.001	2.0 (1.7–2.3)	< 0.001

APACHE-III Acute Physiology And Chronic Health Evaluation-III, BMI body mass index, CCI Charlson comorbidity index, CI confidence interval, IMV invasive mechanical ventilation, NEE norepinephrine equivalents, OR odds ratio
^aUnit odds ratios are represented for continuous variables